... with the severity of acute pancreatitis (AP) and the development of organ failure (OF). Methods: The study comprises 9 severe AP patients with OF and 24 reference patients (11 mild AP and 13 severe AP without OF). Plasma samples were collected on admission. TF-induced thrombin generation in plasma samples...

...Edda Federico; Massimo Falconi; Gianni Zuodar; Giovanni Falconieri; Fabio Puglisi Background: Pancreatic lymphoma is uncommon, representing less than 0.5% of pancreatic tumors, with diffuse large B-cell lymphoma being the predominant histotype. Acute pancreatitis associated with pancreatic lymphoma...

...Marianne Bernardeau; Jean Auroux; Maryan Cavicchi; Corinne Haioun; Laurent Tsakiris; Jean Charles Delchier We report the case of a 33-year-old man who presented with a large B-cell non Hodgkin’s lymphoma presenting as acute pancreatitis. Abdominal CT showed diffuse swelling of the pancreas...

... extragastroduodenal disorders, such as cardiovascular, skin or immunological diseases. The role of Hp infection in acute pancreatitis has not been tested. The aim of this study was to determine the influence of Hp infection on the course of acute ischemia/reperfusion-induced pancreatitis in rats. Methods: Inoculation...

... development of multiple organ dysfunction (MODS) in acute pancreatitis (AP). Methods: AP was induced by the intraductal infusion of 5% sodium taurodeoxycholate in the rat. Tissue endothelial barrier dysfunction (TEBD) was measured by plasma exudation of radiolabeled albumin. Activation of mast cells...

...Vassiliki Mylona; Vassilios Koussoulas; Dimitrios Tzivras; Elias Makrygiannis; Panagiota Georgopoulou; George Koratzanis; Evangelos J. Giamarellos-Bourboulis; Michalis D. Tzivras Background: Acute pancreatitis is a form of inflammation with clinical features ranging from pancreatic inflammation...

...Basem Azab; Neil Jaglall; Jean Paul Atallah; Ari Lamet; Venkat Raja-Surya; Bachir Farah; Martin Lesser; Warren D. Widmann Background: Most acute pancreatitis risk scoring systems use total white blood cell counts (WBC) as one of the risk factors. The value of the neutrophil-lymphocyte ratio (NLR...

... prediction of the severity of acute pancreatitis (AP). Methods: Patients treated for AP from 2002 to 2005 (n = 139) and from 2007 to 2009 (n = 69) were analyzed to develop and validate the ANN model. Severe AP was defined according to the Atlanta criteria. Results: ANNs selected 6 of 23 potential risk...

...Shi-qi Wang; Shu-jun Li; Quan-xin Feng; Xiang-ying Feng; Lei Xu; Qing-chuan Zhao Background/Aims: It is generally accepted that there is a correlation between obesity and poor outcome in acute pancreatitis (AP); however, the relationship between overweight and the prognosis of AP is unknown...

.... Acute pancreatitis Apoptosis Necrosis Polyamine catabolism Spermidine/spermine N 1 -acetyltransferase Trypsinogen activation peptide The polyamines spermidine, spermine, and putrescine are essential to cell growth and many functions important for cell survival. The catabolism of polyamines...

...G.O. Ceyhan; A.-K. Timm; F. Bergmann; A. Günther; A.A. Aghdassi; I.E. Demir; J. Mayerle; M. Kern; M.M. Lerch; M.W. Büchler; H. Friess; P. Schemmer Background/Aims: Acute pancreatitis (AP) is characterized by premature zymogen activation, systemic inflammatory response resulting in inflammatory...

...Catherine M. Pastor; Denis R. Morel; Alain Vonlaufen; Eduardo Schiffer; Pierre Lescuyer; Jean-Louis Frossard Background/Aims: During acute pancreatitis, tumor necrosis factor (TNF)-α, interleukin (IL)-1 and IL-6 play a pivotal role in promoting injury in the pancreas and remote organs. IL- 18...

...M. Bhandari; M. Kawamoto; A.C. Thomas; S.G. Barreto; A.C. Schloithe; C.J. Carati; J. Toouli; G.T.P. Saccone Background/Aims: We compared the galanin antagonists C7, M35, M40 and galantide, for their ability to ameliorate acute pancreatitis (AP). Methods: Galanin antagonists were co-administered...

... the occurrence of acute pancreatitis. Although the presence of symptoms is regarded as a factor for predicting malignant IPMNs, there have been few reports demonstrating whether a history of acute pancreatitis is a predictor of malignancy. The aim of this study was to evaluate the relationship between a history...

...Isaac Samuel; Zuobiao Yuan; David K. Meyerholz; Erik Twait; Deborah E. Williard; Duraisamy Kempuraj Background: Suitable experimental models of gallstone pancreatitis with systemic inflammation and mortality are limited. We developed a novel murine model of duct-ligation-induced acute pancreatitis...

...Z. Tiszlavicz; A. Szabolcs; T. Takács; G. Farkas; R. Kovács-Nagy; E. Szántai; M. Sasvári-Székely; Y. Mándi Aims: Bacterial translocation from the intestinal tract plays an important role in severe acute pancreatitis (AP). Human β-defensins are a family of antimicrobial peptides present...

...Piotr Daniel; Bartosz Leśniowski; Anna Mokrowiecka; Anna Jasińska; Mirosława Pietruczuk; Ewa Małecka-Panas Background: Resistin and visfatin, hormones produced by adipose tissue, have pro-inflammatory potential; however, their role in acute pancreatitis (AP) has been investigated only rarely...

...Maiken Joergensen; Klaus Brusgaard; Dorthe Gylling Crüger; Anne-Marie Gerdes; Ove B. Schaffalitzky de Muckadell Background/Aims: The etiology of acute pancreatitis (AP) seems to have changed during the last two decades, and since detection of mutations in the gene for cationic trypsinogen(PRSS1...

...B.W.M. Spanier; Y. Nio; R.W.M. van der Hulst; H.A.R.E. Tuynman; M.G.W. Dijkgraaf; M.J. Bruno Background: Early computed tomography (CT) (within 4 full days after symptom onset) may be performed to distinguish acute pancreatitis (AP) from other intra-abdominal conditions or to identify early...

...Paul Georg Lankisch This attempt at a historical review of the treatment of acute pancreatitis summarizes the findings of studies carried out in decades long past and shows their impact on the therapy of this disease today. It identifies in retrospect the correct avenues of research and the blind...