... and low response rates to chemotherapy. The prognostic factors identified support the concept of offering systemic chemotherapy to patients with inoperable, advanced disease and of considering metastasectomy in eligible patients. Fig. 2. Kaplan-Meier estimate of median overall survival in 100...

..., instructions or products referred to in the content or advertisements. 2018 Advanced disease Novel treatment strategies Pancreatic cancer Efforts have been made to develop therapeutic small-molecule inhibitors of oncogenic effector signaling cascades downstream of KRAS, namely the Raf-MEK-ERK...

... to modern molecular diagnostic tools. Our review focuses on patients with advanced disease. This includes sarcoma patients with local relapse after initial surgery (with or without radiotherapy), patients with distant metastasis and those with both local relapse and metastasis. Patients with local...