Abstract
Purpose: This study aimed to systematically present application situation and therapeutic effect of proton therapy (PT), heavy ion therapy, and helical tomotherapy (TOMO) for gastric cancer (GC), and to find gaps of existing studies. Methods: PubMed, EMBASE, the Cochrane Library, Web of Science, and Chinese Biological Medical Database were searched. Tables, bubble plot, and heat map were conducted to display results. Results: Fourteen studies were included. About PT, 7 single-arm studies showed median overall survival (OS) within 2–66 months and 1 study reported 40% of patients happened moderate degree of radiation gastritis. About TOMO, 1 study reported longer median OS and progression-free survival, lower occurrence of Grade III toxicity, and late toxicity compared to 3D-CRT, while another study remained neutral. About heavy ion therapy, there was no clinical study was found. Conclusions: Existing studies presented good clinic treatment effect about PT and TOMO for GC, and furthermore clinical studies are needed.
Journal Section:
Systematic Review
References
1.
Mattiuzzi
C
, Lippi
G
. Current cancer epidemiology
. J Epidemiol Glob Health
. 2019
;9
(4
):217
–22
.2.
Schlansky
B
, Sonnenberg
A
. Epidemiology of noncardia gastric adenocarcinoma in the United States
. Am J Gastroenterol
. 2011
;106
(11
):1978
–85
.3.
Johnston
FM
, Beckman
M
. Updates on management of gastric cancer
. Curr Oncol Rep
. 2019
;21
(8
):67
.4.
Zhang
N
, Fei
Q
, Gu
J
, Yin
L
, He
X
. Progress of preoperative and postoperative radiotherapy in gastric cancer
. World J Surg Oncol
. 2018
;16
(1
):187
.5.
Song
Z
, Wu
Y
, Yang
J
, Yang
D
, Fang
X
. Progress in the treatment of advanced gastric cancer
. Tumour Biol
. 2017
;39
(7
):1010428317714626
.6.
Rackwitz
T
, Debus
J
. Clinical applications of proton and carbon ion therapy
. Semin Oncol
. 2019
;46
(3
):226
–32
.7.
Yang
ZX
, Shen
JT
, Li
YP
, Zhao
K
, Shi
CH
, Xiao
Y
, . Helical tomotherapy for cancer treatment: a rapid health technology assessment
. J Evid Based Med
. 2014
;7
(3
):192
–218
.8.
Malouff
TD
, Peterson
JL
, Mahajan
A
, Trifiletti
DM
. Carbon ion radiotherapy in the treatment of gliomas: a review
. J Neurooncol
. 2019
;145
(2
):191
–9
.9.
Lesueur
P
, Calugaru
V
, Nauraye
C
, Stefan
D
, Cao
K
, Emery
E
, . Proton therapy for treatment of intracranial benign tumors in adults: a systematic review
. Cancer Treat Rev
. 2019
;72
:56
–64
.10.
Wang
Z
, Nabhan
M
, Schild
SE
, Stafford
SL
, Petersen
IA
, Foote
RL
, . Charged particle radiation therapy for uveal melanoma: a systematic review and meta-analysis
. Int J Radiat Oncol Biol Phys
. 2013
;86
(1
):18
–26
.11.
Hwang
EJ
, Gorayski
P
, Le
H
, Hanna
GG
, Kenny
L
, Penniment
M
, . Particle therapy tumour outcomes: an updated systematic review
. J Med Imaging Radiat Oncol
. 2020
;64
(5
):711
–24
.12.
Bauman
G
, Yartsev
S
, Rodrigues
G
, Lewis
C
, Venkatesan
VM
, Yu
E
, . A prospective evaluation of helical tomotherapy
. Int J Radiat Oncol Biol Phys
. 2007
;68
(2
):632
–41
.13.
Welsh
JS
, Patel
RR
, Ritter
MA
, Harari
PM
, Mackie
TR
, Mehta
MP
. Helical tomotherapy: an innovative technology and approach to radiation therapy
. Technol Cancer Res Treat
. 2002
;1
(4
):311
–6
.14.
Sun
Y
, Gao
Y
, Chen
J
, Sun
H
, Cai
YT
, Ge
L
, . Evidence mapping of recommendations on diagnosis and therapeutic strategies for diabetes foot: an international review of 22 guidelines
. Metabolism
. 2019
;100
:153956
.15.
Hetrick
SE
, Parker
AG
, Callahan
P
, Purcell
R
. Evidence mapping: illustrating an emerging methodology to improve evidence-based practice in youth mental health
. J Eval Clin Pract
. 2010
;16
(6
):1025
–30
.16.
Jing
XG
, Li
WJ
, Yang
JS
, Guo
CL
, Chu
W
, Jin
XD
, . Oxygen effect in 12C6+ irradiation of BGC823 cells
. Nucl Phys Rev
. 2006
;23
(1
):40
–2
.17.
Miao
GY
, Zhang
H
, Lu
QM
, Li
HY
, Di
CX
, Guo
XY
. Effects of heavy ion irradiation on MSH2 expression in human gastric cancer cell SGC7901
. Nucl Phys Rev
. 2015
;32
(01
):110
–4
.18.
Koyama
S
, Kawanishi
N
, Fukutomi
H
, Osuga
T
, Iijima
T
, Tsujii
H
, . Advanced carcinoma of the stomach treated with definitive proton therapy
. Am J Gastroenterol
. 1990
;85
(4
):443
–7
.19.
Shibuya
S
, Takase
Y
, Aoyagi
H
, Orii
K
, Sharma
N
, Tsujii
H
, . Definitive proton beam radiation therapy for inoperable gastric cancer: a report of two cases
. Radiat Med
. 1991
;9
(1
):35
–40
.20.
Tsujii
H
, Tsuji
H
, Inada
T
, Maruhashi
A
, Hayakawa
Y
, Takada
Y
, . Clinical results of fractionated proton therapy
. Int J Radiat Oncol Biol Phys
. 1993
;25
(1
):49
–60
.21.
Gohongi
T
, Tokuuye
K
, Iida
H
, Nakai
R
, Gunji
N
, Akine
Y
, . Concurrent proton beam radiotherapy and systemic chemotherapy for the metastatic liver tumor of gastric carcinoma: a case report
. Jpn J Clin Oncol
. 2005
;35
(1
):40
–4
.22.
Chopra
S
, Agarwal
A
, Engineer
R
, Paul
S
, Thomas
B
, Mehta
S
, . Acute toxicity and compliance with tomotherapy based adjuvant intensity modulated radiotherapy in patients with gastric cancer: results from prospective study
. Ann Oncol
. 2013
;24
:iv63
.23.
Dionisi
F
, Amelio
D
, Cianchetti
M
, Iannacone
E
, Ravanelli
D
, Rombi
B
, . Clinical experience with proton therapy for gastrointestinal cancers: a review
. J Gastroenterol Hepatol Res
. 2013
;2
(12
):897
–904
.24.
Plastaras
JP
, Dionisi
F
, Wo
JY
. Gastrointestinal cancer: nonliver proton therapy for gastrointestinal cancers
. Cancer J
. 2014
;20
(6
):378
–86
.25.
Chopra
S
, Agarwal
A
, Engineer
R
, Dora
T
, Thomas
B
, Sonawone
S
, . Intensity modulated radiation therapy (IMRT) is not superior to three-dimensional conformal radiation (3DCRT) for adjuvant gastric radiation: a matched pair analysis
. J Cancer Res Ther
. 2015
;11
(3
):623
–9
.26.
Verma
V
, Lin
SH
, Simone
CB
, Mehta
MP
. Clinical outcomes and toxicities of proton radiotherapy for gastrointestinal neoplasms: a systematic review
. J Gastrointest Oncol
. 2016
;7
(4
):644
–64
.27.
Fukumitsu
N
, Okumura
T
, Takizawa
D
, Numajiri
H
, Ohnishi
K
, Mizumoto
M
, . Proton beam therapy for liver metastases from gastric cancer
. J Radiat Res
. 2017
;58
(3
):357
–62
.28.
Badiyan
SN
, Hallemeier
CL
, Lin
SH
, Hall
MD
, Chuong
MD
. Proton beam therapy for gastrointestinal cancers: past, present, and future
. J Gastrointest Oncol
. 2018
;9
(5
):962
–71
.29.
Kucuktulu
E
, Yurekli
AF
, Topbas
M
, Kece
C
, Guner
A
, Kucuktulu
U
. Comparisons between the dosimetric and clinical outcomes of tomotherapy and 3D conformal radiotherapy in gastric cancer treatment
. Asian Pac J Cancer Prev
. 2019
;20
(2
):595
–9
.30.
Nakajima
K
, Iwata
H
, Hattori
Y
, Hashimoto
S
, Hayashi
K
, Toshito
T
, . Image-guided proton therapy (IGPT) for oligometastatic liver tumors from gastric/colorectal cancer
. Int J Radiat Oncol Biol Phys
. 2019
;105
(1
):E224
–5
.31.
Yamaguchi
H
, Honda
M
, Hamada
K
, Kobayashi
H
, Todate
Y
, Seto
I
, . The effectiveness of proton beam therapy for liver metastatic recurrence in gastric cancer patients
. Jpn J Clin Oncol
. 2020
;50
(8
):903
–8
.32.
Cox
JD
, Stetz
J
, Pajak
TF
. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)
. Int J Radiat Oncol Biol Phys
. 1995
;31
(5
):1341
–6
.33.
Tokunaga
M
, Sato
Y
, Nakagawa
M
, Aburatani
T
, Matsuyama
T
, Nakajima
Y
, . Perioperative chemotherapy for locally advanced gastric cancer in Japan: current and future perspectives
. Surg Today
. 2020
;50
(1
):30
–7
.34.
Tatsubayashi
T
, Tanizawa
Y
, Miki
Y
, Tokunaga
M
, Bando
E
, Kawamura
T
, . Treatment outcomes of hepatectomy for liver metastases of gastric cancer diagnosed using contrast-enhanced magnetic resonance imaging
. Gastric Cancer
. 2017
;20
(2
):387
–93
.35.
Kinoshita
T
, Kinoshita
T
, Saiura
A
, Esaki
M
, Sakamoto
H
, Yamanaka
T
. Multicentre analysis of long-term outcome after surgical resection for gastric cancer liver metastases
. Br J Surg
. 2015
;102
(1
):102
–7
.36.
Morise
Z
, Sugioka
A
, Hoshimoto
S
, Kato
T
, Ikeda
M
, Uyama
I
, . The role of hepatectomy for patients with liver metastases of gastric cancer
. Hepatogastroenterology
. 2008
;55
(85
):1238
–41
.37.
Mohan
R
, Grosshans
D
. Proton therapy: present and future
. Adv Drug Deliv Rev
. 2017
;109
:26
–44
.38.
Amichetti
M
, Cianchetti
M
, Amelio
D
, Enrici
RM
, Minniti
G
. Proton therapy in chordoma of the base of the skull: a systematic review
. Neurosurg Rev
. 2009
;32
(4
):403
–16
.39.
LaRiviere
MJ
, Santos
PMG
, Hill-Kayser
CE
, Metz
JM
. Proton therapy
. Hematol Oncol Clin North Am
. 2019
;33
(6
):989
–1009
.40.
Murad
MH
, Asi
N
, Alsawas
M
, Alahdab
F
. New evidence pyramid
. Evid Based Med
. 2016
;21
(4
):125
–7
.41.
Mohamad
O
, Yamada
S
, Durante
M
. Clinical Indications for carbon ion radiotherapy
. Clin Oncol (R Coll Radiol)
. 2018
;30
(5
):317
–29
.42.
Hu
M
, Jiang
L
, Cui
X
, Zhang
J
, Yu
J
. Proton beam therapy for cancer in the era of precision medicine
. J Hematol Oncol
. 2018
;11
(1
):136
.43.
Tinganelli
W
, Durante
M
, Hirayama
R
, Krämer
M
, Maier
A
, Kraft-Weyrather
W
, . Kill-painting of hypoxic tumours in charged particle therapy
. Sci Rep
. 2015
;5
:17016
.44.
Peeters
A
, Grutters
JP
, Pijls-Johannesma
M
, Reimoser
S
, De Ruysscher
D
, Severens
JL
, . How costly is particle therapy? Cost analysis of external beam radiotherapy with carbon-ions, protons and photons
. Radiother Oncol
. 2010
;95
(1
):45
–53
.45.
Sprave
T
, Verma
V
, Sterzing
F
, Bruckner
T
, Hees
K
, Land
B
, . Cost-effectiveness of carbon ion radiation therapy for skull base chordoma utilizing long-term (10-year) outcome data
. Anticancer Res
. 2018
;38
(8
):4853
–8
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