Introduction: Breast cancer is responsible for more than 50% of cutaneous metastases. One of the treatment options is electrochemotherapy (ECT). It is an effective method of local tumor ablation through the application of electroporation. The primary objective of the study was to demonstrate a response to the treatment in our group of patients. Methods: Between February 2015 and October 2016, in 3 centers in Poland, 47 ECT procedures were performed in 38 patients with metastasis of breast cancer to the skin. Results: At 12 weeks after the procedures, 71% of patients showed a positive response to the treatment (42% with complete response, and 29% with partial response). Multivariate analysis demonstrated that only the estrogen receptor status and the size of the metastatic lesion were predictive of overall response (p = 0.0243 and p = 0.03716, respectively). Conclusion: The results of our study demonstrate a high effectiveness of ECT in the treatment of cutaneous metastasis from breast cancer. This method, although used for palliative treatment, brings a significant improvement in the quality of life of patients.

Benevento R, Santoriello A, Perna G, Canonico S: Electrochemotherapy of cutaneous metastastes from breast cancer in elderly patients: A preliminary report. BMC Surg 2012;12(Suppl 1):S6.
Wojciechowska U, Didkowska J: Incident rates and deaths from malignant tumors in Poland. National Cancer Registry, Oncology Center - Instytut im. Maria Skłodowska - Curie. Epub 2017 Dec 31.
Krathen RA, Orengo IF, Rosen T: Cutaneous metastasis: A meta-analysis of data. South Med J 2003;96:164-167.
Hu SC, Chen GS, Lu YW, et al.: Rates of cutaneous metastases from different internal malignancies: Experience from a Taiwanese medical center. J Am Acad Dermatol 2009;60:379-387.
Lookingbill DP, Spangler N, Helm KF: Cutaneous metastases in patients with metastatic carcinoma: A retrospective study of 4020 patients. J Am Acad Dermatol 1993;29:228-236.
Mir LM, Belehradek M, Domenge C, et al.: Electrochemotherapy, a new antitumor treatment: First clinical trial. C R Acad Sci III 1991;313:612-618.
Marty M, Sersa G, Garbay JR: Electrochemotherapy - An easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study. EJC 2006;Suplement 4:3-13.
Mir ML, Gehl J, Sersa G, et al.: Standard operating procedures of the electrochemotherapy: Instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the Cliniporator by means of invasive or non-invasive electrodes. EJC 2006;Suplement 4:14-25.
Campana LG, Testori A, Curatolo P, et al.: Treatment efficacy with electrochemotherapy: A multi-institutional prospective observational study on 376 patients with superficial tumors. Eur J Surg Oncol 2016;42:1914-1923.
Bourke MG, Salwa SP, Sadadcharam M, et al.: Effective treatment of intractable cutaneous metastases of breast cancer with electrochemotherapy: Ten-year audit of single centre experience. Breast Cancer Res Treat 2017;161:289-297.
Wichtowski M, Murawa D, Kulcenty K, Zaleska K: Electrochemotherapy in breast cancer - discussion of the method and literature review. Breast Care 2017;12:409-414.
Matthiessen LW, Keshtgar M, Curatolo P, et al.: Electrochemotherapy for breast cancer-Results from the INSPECT database. Clin Breast Cancer 2018;18:e909-e917.
Grischke EM, Röhm C, Stauß E, et al.: Electrochemotherapy - Supplementary treatment for loco-regional metastasized breast carcinoma administered to concomitant systemic therapy. Radiol Oncol 2017;51:317-323.
Gehl J, Sersa G, Matthiessen LW, et al.: Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases. Acta Oncol 2018;57:874-882.
Spratt DE, Gordon Spratt EA, Wu S, et al.: Efficacy of skin-directed therapy for cutaneous metastases from advanced cancer: A meta analysis. J Clin Oncol 2014;32:3144-3155.
Wichtowski M, Potocki P, Kufel-Grabowska J, et al.: Electrochemotherapy in the treatment of massive, multisite breast cancer metastasis to the skin and subcutaneous tissue: A case report. Breast Care 2016;11:353-355.
Orlowski S, Belehradek J Jr, Paoletti C, Mir LM: Transient electropermeabilization of cells in culture. Increase of the cytotoxicity of anticancer drugs. Biochem Phar 1988;37:4727-4733.
Larkin JO, Collins CG, Aarons S, et al.: Electrochemotherapy: Aspects of preclinical development and early clinical experience. Ann Surg 2007;245:469-479.
Jarm T, Cemazar M, Miklavcic D, Serca G: Antivascular effects of electrochemotherapy: Implications in treatment of bleeding metastases. Expert Rev Anticancer Ther 2010;10:729-746.
Cemazar M, Parkins CS, Holder AL, et al.: Electroporation of human microvascular endothelial cells: Evidence for an anti-vascular mechanism of electrochemotherapy. Br J Cancer 2001;84:565-570.
Groselj A, Kranjc S, Bosnjak M, et al.: Vascularization of the tumours affects the pharmacokinetics of bleomycin and the effectiveness of electrochemotherapy. Basic Clin Pharmacol Toxicol 2018;123:247-256.
Sersa G, Cemazar M, Menart V, et al.: Antitumor effectiveness of electrochemotherapy with bleomycin is increased by TNF-alfa on SA-1 tumors in mice. Cancer Lett 1997;116:85-92.
Cabula C: Neoadjuvant electrochemotherapy of breast cancer: Our experience on first case treated in Italy. Updates Surg 2013;65:325-328.
Mali B, Jarm T, Snoj M, et al.: Antitumor effectiveness of electrochemotherapy: A systemic review and meta-analysis. Eur J Surg Oncol 2013;39:4-16.
De Virgilio A, Ralli M, Longo L, et al.: Electrochemotherapy in head and neck cancer: A review of an emerging cancer treatment. Oncol Lett 2018;16:3415-3423.
Seyed Jafari SM, Jabbary Lak F, Gazdhar A, et al.: Application of electrochemotherapy in the management of primary and metastatic cutaneous malignant tumours: A systematic review and meta-analysis. Eur J Dermatol 2018;28:287-313.
Girelli R, Prejanò S, Cataldo I, et al.: Feasibility and safety of electrochemotherapy (ECT) in the pancreas: A pre-clinical investigation. Radiol Oncol 2015;49:147-154.
Tafuto S, von Arx C, De Divitiis C, et al.: Electrochemotherapy as a new approach on pancreatic cancer and on liver metastases. Int J Surg 2015;21(Suppl 1):78-82.
Diagnosis and Treatment of Patients with Primary and Metastatic Breast Cancer. Loco-regional recurrence. 2015;
National Institute for Health and Care Excellence. Electrochemotherapy for metastases in the skin from tumors of non-skin origin and melanoma. Interventional procedure guidance. 2013;
You do not currently have access to this content.