Objectives: The clinicopathological characteristics, treatment modalities, and effects on the prognosis of pure squamous cell carcinoma (SqCC) and adenocarcinoma (AC) were evaluated. Materials and Methods: 86 patients with pure SqCC and AC bladder cancer were evaluated retrospectively. Results: Of the 86 patients, 51 had SqCC and 35 had AC. No differences in clinicopathological characteristics were observed between patients with AC and SqCC, except for the prevalence of T4 disease (28.6% vs. 51.0%, respectively). In multivariate analysis, older age, stage IV disease, and Eastern Cooperative Oncology Group (ECOG) performance status (> 2) were predictive of a poor overall survival (OS). The median OS was significantly longer for stage I-III patients (82.9 months) treated with surgery ± chemotherapy (CT) ± radiotherapy (RT) than for those treated with transurethral resection ± CT ± RT (24.3 months) (P = 0.007). The median OS of patients with SqCC and AC who were given platinum-based CT for metastasis was 7.7 and 30.3 months, respectively. Conclusions: Advanced age, stage IV disease, and poor ECOG performance status were factors associated with a poor prognosis. Surgery ± CT ± RT resulted in significantly better OS, except in stage IV disease. Patients with metastatic AC had better response rates with platinum-based CT.

1.
SEER Cancer Statistics Factsheets: Bladder Cancer. Bethesda, National Cancer Institute, http://seer.cancer.gov/statfacts/html/urinb.html.
2.
Dahm P, Gschwend JE: Malignant non-urothelial neoplasms of the urinary bladder: a review. Eur Urol 2003;44:672-681.
3.
Murphy WM, Beckwith JB, Farrow GM: Tumors of the kidney, bladder and related urinary structures; in Atlas of Tumor Pathology, vol 3, 3rd series, fascicle 11. Washington, Armed Forces Institute of Pathology, 1994, pp 193-288.
4.
Mostofi FK, Thomson RV, Dean AL Jr: Mucous adenocarcinoma of the urinary bladder. Cancer 1955;8:741-758.
5.
Sheldon CA, Clayman RV, Gonzalez R, Williams RD, Fraley EE: Malignant urachal lesions. J Urol 1984;131:1-8.
6.
AJCC Cancer Staging Manual, ed 7. Chicago, American Joint Committee on Cancer, 2010, pp 497-502.
7.
Abdollah F, Sun M, Jeldres C, Schmitges J, Thuret R, Djahangirian O, Tian Z, Shariat SF, Perrotte P, Montorsi F, Karakiewicz PI: Survival after radical cystectomy of non-bilharzial squamous cell carcinoma vs urothelial carcinoma: a competing-risks analysis. BJU Int 2012;109:564-569.
8.
El-Sebaie M, Zaghloul MS, Howard G, Mokhtar A: Squamous cell carcinoma of the bilharzial and non-bilharzial urinary bladder: a review of etiological features, natural history, and management. Int J Clin Oncol 2005;10:20-25.
9.
Izard JP, Siemens DR, Mackillop WJ, Wei X, Leveridge MJ, Berman DM, Peng Y, Booth CM: Outcomes of squamous histology in bladder cancer: a population-based study. Urol Oncol 2015;33:425.e7-13.
10.
Lagwinski N, Thomas A, Stephenson AJ, Campbell S, Hoschar AP, El-Gabry E, Dreicer R, Hansel DE: Squamous cell carcinoma of the bladder: a clinicopathologic analysis of 45 cases. Am J Surg Pathol 2007;31:1777-1787.
11.
Ploeg M, Aben KK, Hulsbergen-van de Kaa CA, Schoenberg MP, Witjes JA, Kiemeney LA: Clinical epidemiology of nonurothelial bladder cancer: analysis of the Netherlands Cancer Registry. J Urol 2010;183:915-920.
12.
Grignon DJ, Ro JY, Ayala AG, Johnson DE, Ordonez NG: Primary adenocarcinoma of the urinary bladder. A clinicopathologic analysis of 72 cases. Cancer 1991;67:2165-2172.
13.
Zaghloul MS, Nouh A, Nazmy M, Ramzy S, Zaghloul AS, Sedira MA, Khalil E: Long-term results of primary adenocarcinoma of the urinary bladder: a report on 192 patients. Urol Oncol 2006;24:13-20.
14.
Manunta A, Vincendeau S, Kiriakou G, Lobel B, Guille F: Non-transitional cell bladder carcinomas. BJU Int 2005;95:497-502.
15.
Rundle JS, Hart AJ, McGeorge A, Smith JS, Malcolm AJ, Smith PM: Squamous cell carcinoma of bladder. A review of 114 patients. Br J Urol 1982;54:522-526.
16.
Guo CC, Gomez E, Tamboli P, Bondaruk JE, Kamat A, Bassett R, Dinney CP, Czerniak BA: Squamous cell carcinoma of the urinary bladder: a clinicopathologic and immunohistochemical study of 16 cases. Hum Pathol 2009;40:1448-1452.
17.
Anderstrom C, Johansson SL, von Schultz L: Primary adenocarcinoma of the urinary bladder. A clinicopathologic and prognostic study. Cancer 1983;52:1273-1280.
18.
Rogers CG, Palapattu GS, Shariat SF, Karakiewicz PI, Bastian PJ, Lotan Y, Gupta A, Vazina A, Gilad A, Sagalowsky AI, Lerner SP, Schoenberg MP: Clinical outcomes following radical cystectomy for primary nontransitional cell carcinoma of the bladder compared to transitional cell carcinoma of the bladder. J Urol 2006;175:2048-2053; discussion 2053.
19.
Sakkas JL: Clinical pattern and treatment of squamous cell carcinoma of the bladder. Int Surg 1966;45:71-76.
20.
Arslan B, Bozkurt IH, Yonguc T, Vardar E, Degirmenci T, Kozacioglu Z, Gunlusoy B, Minareci S: Clinical features and outcomes of nontransitional cell carcinomas of the urinary bladder: analysis of 125 cases. Urol Ann 2015;7:177-182.
21.
el-Mekresh MM, el-Baz MA, Abol-Enein H, Ghoneim MA: Primary adenocarcinoma of the urinary bladder: a report of 185 cases. Br J Urol 1998;82:206-212.
22.
Girgin C, Sezer A, Uc R, Ermete M, Ozkan U, Gurel G: Outcome of the treatment of invasive non-transitional cell carcinoma. Int J Urol 2003;10:525-529.
23.
Richie JP, Waisman J, Skinner DG, Dretler SP: Squamous carcinoma of the bladder: treatment by radical cystectomy. J Urol 1976;115:670-672.
24.
Dandekar NP, Dalal AV, Tongaonkar HB, Kamat MR: Adenocarcinoma of bladder. Eur J Surg Oncol 1997;23:157-160.
25.
Johnson DE, Schoenwald MB, Ayala AG, Miller LS: Squamous cell carcinoma of the bladder. J Urol 1976;115:542-544.
26.
Swanson DA, Liles A, Zagars GK: Preoperative irradiation and radical cystectomy for stages T2 and T3 squamous cell carcinoma of the bladder. J Urol 1990;143:37-40.
27.
Hong JY, Choi MK, Uhm JE, Park MJ, Lee J, Park SH, Park JO, Kim WS, Kang WK, Lee HM, Choi HY, Lim H: Palliative chemotherapy for non-transitional cell carcinomas of the urothelial tract. Med Oncol 2009;26:186-192.
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