Background: Kaposiform hemangioendothelioma (KHE) is a rare vascular neoplasm that mainly affects infants. KHE rarely develops in adolescents and adults. These tumors tend to be locally invasive, but are not known to produce distant metastases. Numerous treatment modalities are available for KHE, but the optimal therapy is unknown. Case Report: A 51-year-old woman was diagnosed with KHE of the ilium in September 2005. The lesion recurred within 5 years of local excision, and was subsequently treated with CyberKnife. Within 1 month of CyberKnife therapy, pain intensity was significantly reduced and the patient's quality of life was significantly improved. Since January 2011, she has remained pain-free and has had no signs of recurrence or metastasis for more than 2 years following CyberKnife therapy. Conclusion: We report the first CyberKnife treatment of an adult with KHE of the bone without accompanying cutaneous changes and Kasabach-Merritt syndrome. CyberKnife treatment could be a useful temporizing measure for bone KHE.

Journal Section:
Novel Insights from Clinical Practice
Keywords:
Kaposiform hemangioendothelioma, Kasabach-Merritt syndrome, CyberKnife
1.
Mentzel T, Mazzoleni G, Dei Tos AP, Fletcher CD: Kaposiform hemangioendothelioma in adults. Clinicopathologic and immunohistochemical analysis of three cases. Am J Clin Pathol 1997; 108:405-455.
[PubMed]
2.
Zamecnik M, Mikleova Z, Michal M: Kaposiform hemangioendothelioma in adult. Report of a case with amianthoid-like fibrosis and angiectases. Ceskoslov Patol 2000;36:163-167.
[PubMed]
3.
Mac-Moune Lai F, To KF, Choi PC, Leung PC, Kumta SM, Yuen PP, Lam WY, Cheung AN, Allen PW: Kaposiform hemangioendithelioma: five patients with cutaneous lesions and long follow-up. Mod Pathol 2001;14:1087-1092.
[PubMed]
https://doi.org/10.1038/modpathol.3880441
4.
Cooper JG, Edwards SL, Holmes JD: Kaposiform haemangioendothelioma: case report and review of the literature. Br J Plast Surg 2002;55:163-165.
[PubMed]
https://doi.org/10.1054/bjps.2001.3769
5.
Hardisson D, Prim MP, De Diego JI, Patrón M, Escribano A, Rabanal I: Kaposiform hemangioendothelioma of the external auditory canal in an adult. Head Neck 2002;24:614-617.
[PubMed]
https://doi.org/10.1002/hed.10074
6.
Lyons LL, North PE, Mac-Moune Lai F, Stoler MH, Folpe AL, Weiss SW: Kaposiform hemangioendothelioma: a study of 33 cases emphasizing its pathologic, immunophenotypic, and biologic uniqueness from juvenile hemangioma. Am J Surg Pathol 2004;28:559-568.
[PubMed]
https://doi.org/10.1097/00000478-200405000-00001
7.
El-Sayed N, Ramadan M: Immunohistochemical study of some rare vascular tumors. J Egypt Natl Cancer Inst 2004;16:123-129.
[PubMed]
8.
Senturk N, Y'yldiz L, Aydin F, Eroglu L, Canturk T, Turanli AY: Kaposiform hemangioendothelioma in an adult with an unusual presentation. J Eur Acad Dermatol Venereol 2006;20:630-632.
[PubMed]
https://doi.org/10.1111/j.1468-3083.2006.01524.x
9.
Bienaimé A, Rojat-Habib MC, Hesse S, Pelissier JF, Bonerandi JJ: Giant vascular tumour in an adult: tufted angioma or kaposiform hemangioendothelioma. Am Dermatol Venereol 2006; 133:553-556.
[PubMed]
https://doi.org/10.1016/S0151-9638(06)70961-9
10.
Cho SH, Na KS: Haemangioendothelioma on the conjunctiva of the upper eyelid. Clin Experiment Ophthalmol 2006;34:794-796.
[PubMed]
https://doi.org/10.1111/j.1442-9071.2006.01320.x
11.
Vetter-Kauczok CS, Ströbel P, Bröcker EB, Becker JC: Kaposiform hemangioendothelioma with distant lymphangiomatosis without an association to Kasabach-Merritt-Syndrome in a female adult. Vasc Health Risk Manag 2008;4:263-266.
[PubMed]
https://doi.org/10.2147/vhrm.2008.04.01.263
12.
White JB, Pullman J, Wenig B, Smith RV: Kaposiform hemangioendothelioma of the tongue in an adult. Arch Otolaryngol Head Neck Surg 2009;135: 824-826.
[PubMed]
https://doi.org/10.1001/archoto.2009.104
13.
Karnes JC, Lee BT, Phung T, Alomari AI, Mulliken JB, Greene AK: Adult-onset kaposiform hemangio endothelioma in a posttraumatic site. Ann Plast Surg 2009;62:456-458.
[PubMed]
https://doi.org/10.1097/SAP.0b013e318184aafc
14.
Kim MG, Choi YS, Park SJ, Chong SM: Kaposiform hemangioendothelioma of the breast in an adult female. Clin Breast Cancer 2011;11:135-137.
[PubMed]
https://doi.org/10.1016/j.clbc.2011.03.008
15.
Yu L, Yang SJ: Kaposiform hemangioendothelioma of the spleen in an adult: an initial case report. Pathol Oncol Res 2011;17:969-972.
[PubMed]
https://doi.org/10.1007/s12253-010-9331-1
16.
Costa FD, Folpe AL: Intratesticular kaposiform haemangioendothelioma in adults: a report of two cases. J Clin Pathol 2013;66:623-626.
[PubMed]
https://doi.org/10.1136/jclinpath-2013-201478
17.
Croteau SE, Liang MG, Kozakewich HP, Alomari AI, Fishman SJ, Mulliken JB, Trenor CC 3rd: Kaposiform hemangioendothelioma: atypical features and risks of Kasabach-Merritt phenomenon in 107 referrals. J Pediatr 2013;162:142-147.
[PubMed]
https://doi.org/10.1016/j.jpeds.2012.06.044
18.
Drolet BA, Trenor CC 3rd, Brandão LR, Chiu YE, Chun RH, Dasgupta R, Garzon MC, Hammill AM, Johnson CM, Tlougan B, et al.: Consensus-derived practice standards plan for complicated kaposiform hemangioendothelioma. J Pediatr 2013;163:285-291.
[PubMed]
https://doi.org/10.1016/j.jpeds.2013.03.080
19.
Lai FM, Allen PW, Yuen PM, Leung PC: Locally metastasizing vascular tumor: spindle cell, epithelioid, or unclassified hemangioendothelioma? Am J Clin Pathol 1991;96:660-663.
[PubMed]
20.
Vin-Christian K, McCalmont TH, Frieden IJ: Kaposiform hemangioendothelioma. An aggressive, locally invasive vascular tumor that can mimic hemangioma of infancy. Arch Dermatol 1997;133:1573-1578.
[PubMed]
https://doi.org/10.1001/archderm.1997.03890480093014
21.
Lalaji TA, Haller JO, Burgess RJ: A case of head and neck kaposiform hemangioendothelioma simulating a malignancy on imaging. Pediatr Radiol 2001;31:876-878.
[PubMed]
https://doi.org/10.1007/s002470100009
22.
DeFatta RJ, Verret DJ, Adelson RT, Gomez A, Myers LL: Kaposiform hemangioendothelioma: case report and literature review. Laryngoscope 2005;115:1789-1792.
[PubMed]
https://doi.org/10.1097/01.mlg.0000176539.94515.75
23.
Gruman A, Liang MG, Mulliken JB, Fishman SJ, Burrows PE, Kozakewich HP, Blei F, Frieden IJ: Kaposiform hemangioendothelioma without Kasabach-Merritt phenomenon. J Am Acad Dermatol 2005;52:616-622.
[PubMed]
https://doi.org/10.1016/j.jaad.2004.10.880
24.
Lisle JW, Bradeen HA, Kalof AN: Kaposiform hemangioendothelioma in multiple spinal levels without skin changes. Clin Orthop Relat Res 2009;467:2464-2471.
[PubMed]
https://doi.org/10.1007/s11999-009-0838-2
25.
Ma J, Shi QL, Jiang SJ, Zhou HB, Zhou XJ: Primary kaposiform hemangioendothelioma of a long bone: two cases in unusual locations with long-term follow up. Pathol Int 2011;61:382-386.
[PubMed]
https://doi.org/10.1111/j.1440-1827.2011.02681.x
26.
Zhu Y, Qiu G, Zhao H, Liang J, Shi X: Kaposiform hemangioendothelioma with adolescent thoracic scoliosis: a case report and review of literature. Eur Spine J 2011;20(suppl 2):309-313.
[PubMed]
https://doi.org/10.1007/s00586-011-1731-8
27.
Saito M, Gunji Y, Kashii Y, Odaka J, Yamauchi T, Kanai N, Momoi MY: Refractory kaposiform hemangioendothelioma that expressed vascular endothelial growth factor receptor (VEGFR)-2 and VEGFR-3: a case report. J Pediatr Hematol Oncol 2009;31:194-197.
[PubMed]
https://doi.org/10.1097/MPH.0b013e3181979c83
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