Das als Verursacher des Botulismus bekannte Toxin des Clostridium botulinum ist das stÄrkste bekannte Gift. Durch Blockade der AcetylcholinausschÜttung in den neuromuskulÄren Synapsenspalt fÜhrt es zu chemischer Denervierung der Muskulatur. In geeigneter VerdÜnnung kommt es bei intramuskulÄrer Injektion nur zu lokaler Wirkung, die zur Therapie fokaler Dystonien eingesetzt wird. Die Autoren berichten Über ihre ersten Erfahrungen bei der Behandlung des Torticollis spasmodicus. Die Methode der elektromyographisch kontrollierten Injektionstechnik wird vorgestellt. Anhand von Fallbeispielen werden die Therapieerfolge veranschaulicht.

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