Abstract
Granulocytic sarcoma is a myeloid neoplasm that can occur in isolation or in association with acute leukaemia. The temporal bone represents a sanctuary site for myeloid progenitors: granulocytic sarcoma may develop in this location before or concomitantly with the onset of acute leukaemia. This atypical presentation with clinical and radiological data that closely mimic those of cholesteatoma often delays an accurate diagnosis. We here describe the clinical case of a 28-year-old male with granulocytic sarcoma of the external auditory canal that preceded the relapse of promyelocytic leukaemia.
Journal Section:
Case Report
References
1.
Shallis
RM
, Gale
RP
, Lazarus
HM
, Roberts
KB
, Xu
ML
, Seropian
SE
. Myeloid sarcoma, chloroma, or extramedullary acute myeloid leukemia tumor: a tale of misnomers, controversy and the unresolved
. Blood Rev
. 2021
;47
:100773
.2.
Lafayette
TCS
, Coser
VM
, Brûlé
AO
, Coser
PL
, Pereira
WV
. External auditory canal and middle ear relapse of acute promyelocytic leukemia treated with arsenic trioxide: case report and review of the literature
. J Pediatr Hematol Oncol
. 2010
;32
(3
):229
–32
.3.
Thompson
DH
, Ross
DG
, Reid
JW
. Granulocytic sarcoma (chloroma) initially seen as acute mastoiditis
. Arch Otolaryngol
. 1982
;108
(6
):388
–91
.4.
Chen
SM
, Silverman
DA
, Jatana
KR
, Chiang
T
, Guinipero
T
, Hill
N
. Myeloid sarcoma presenting as bilateral acute otitis externa in newly diagnosed acute myeloid leukemia
. Int J Pediatr Otorhinolaryngol
. 2019 Jul
122
126
9
. Epub 2019 Apr 3. 5.
Breccia
M
, Petti
MC
, Testi
AM
, Specchia
G
, Ferrara
F
, Diverio
D
. Ear involvement in acute promyelocytic leukemia at relapse: a disease-associated “sanctuary?”
. Leukemia
. 2002 Jun
16
6
1127
30
.6.
Li
Q
, Yang
C
, Liu
WB
, Li
ZX
, Jiang
HQ
. A case of facial paralysis caused by granulocytic sarcoma of the external auditory canal
. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
. 2018 Aug
32
16
1278
9
.7.
Prasad
SC
, D’Orazio
F
, Medina
M
, Bacciu
A
, Sanna
M
. State of the art in temporal bone malignancies
. Curr Opin Otolaryngol Head Neck Surg
. 2014 Apr
22
2
154
65
.8.
Cumberworth
VL
, Friedmann
I
, Glover
GW
. Late metastasis of breast carcinoma to the external auditory canal
. J Laryngol Otol
. 1994 Sep
108
9
808
10
.9.
Carr
S
, Anderson
C
. Metastatic rectal adenocarcinoma in the external auditory canal
. J Laryngol Otol
. 2009 Mar
123
3
363
4
. Epub 2008 Jun 4. 10.
Yasumatsu
R
, Okura
K
, Sakiyama
Y
, Nakamuta
M
, Matsumura
T
, Uehara
S
. Metastatic hepatocellular carcinoma of the external auditory canal
. World J Gastroenterol
. 2007 Dec 21
13
47
6436
8
.11.
de Arruda
JAA
, Mesquita
RA
, Canedo
NHS
, Agostini
M
, Abrahão
AC
, de Andrade
BAB
. Merkel cell carcinoma of the lower lip: a case report and literature review
. Oral Oncol
. 2021 Feb
113
105019
. Epub 2020 Sep 26. 12.
Seifert
RP
, Bulkeley
W
3rd, Zhang
L
, Menes
M
, Bui
MM
. A practical approach to diagnose soft tissue myeloid sarcoma preceding or coinciding with acute myeloid leukemia
. Ann Diagn Pathol
. 2014 Aug
18
4
253
60
. Epub 2014 Jun 13. 13.
Chen
G
, Xu
H
, Yao
Y
, Xu
T
, Yuan
M
, Zhang
X
. BMP signaling in the development and regeneration of cranium bones and maintenance of calvarial stem cells
. Front Cell Dev Biol
. 2020 Mar 10
8
135
.14.
Jin
SW
, Sim
KB
, Kim
SD
. Development and growth of the normal cranial vault: an embryologic review
. J Korean Neurosurg Soc
. 2016 May
59
3
192
6
. Epub 2016 May 10. 15.
Yoshida
T
, Vivatbutsiri
P
, Morriss-Kay
G
, Saga
Y
, Iseki
S
. Cell lineage in mammalian craniofacial mesenchyme
. Mech Dev
. 2008
125
9–10
797
808
.16.
Lefort
S
, Maguer-Satta
V
. Targeting BMP signaling in the bone marrow microenvironment of myeloid leukemia
. Biochem Soc Trans
. 2020
;48
(2
):411
–8
.17.
Gruszka
AM
, Valli
D
, Alcalay
M
. Wnt signalling in acute myeloid leukaemia
. Cells
. 2019 Nov 7
8
11
1403
.18.
Przewoźny
TT
, Kosiński
A
, Markiet
K
, Sierszeń
W
, Kuczkowski
J
, Kuryłowicz
J
. Körner’s septum (petrosquamosal lamina): the anatomical variant or clinical problem
. Folia Morphol
. 2020
;79
(2
):205
–10
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