Introduction: Radiofrequency turbinate volume reduction (RFTVR) is an effective treatment of inferior turbinate hypertrophy. RFTVR can reduce epithelial cell alterations in nasal mucosa. The aim of this observational study was to evaluate the effects of RFTVR on nasal obstruction and cytology, stratifying for different types of rhinitis. Methods: Nasal cytology and subjective nasal obstruction were evaluated on 113 patients before RFTVR (T0) and after 3 months (T1). The patients were divided into groups on the basis of the underlying disease: allergic rhinitis, nonallergic rhinitis, rhinitis medicamentosa, and other diseases (e.g., hormonal-based turbinate hypertrophy). Results: Nasal cytology at T0 identified 42 patients with allergic rhinitis, 40 with nonallergic rhinitis, 19 with rhinitis medicamentosa, and 12 with other diseases. An improvement of nasal cytology at T1 was observed in 29.2% of cases. They mainly consisted of patients with nonallergic rhinitis with neutrophils, whose neutrophil infiltrate decreased. Only 2 cases (1.7%) showed a worsening of nasal cytology at T1. A statistically significant decrease in subjective nasal obstruction was observed for every group (p < 0.05). Higher differences of nasal obstruction between T0 and T1 were found in patients with rhinitis medicamentosa or other diseases. Conclusion: RFTVR represents a safe and effective treatment for turbinate hypertrophy of various etiology. It is not responsible for a worsening of inflammatory infiltrate of the nasal mucosa.

1.
Garzaro
M
,
Pezzoli
M
,
Pecorari
G
,
Landolfo
V
,
Defilippi
S
,
Giordano
C
.
Radiofrequency inferior turbinate reduction: an evaluation of olfactory and respiratory function
.
Otolaryngol Head Neck Surg
.
2010
;
143
(
3
):
348
52
. .
2.
Garzaro
M
,
Pezzoli
M
,
Landolfo
V
,
Defilippi
S
,
Giordano
C
,
Pecorari
G
.
Radiofrequency inferior turbinate reduction: long-term olfactory and functional outcomes
.
Otolaryngol Head Neck Surg
.
2012
;
146
(
1
):
146
50
. .
3.
Chhabra
N
,
Houser
SM
.
Surgery for allergic rhinitis
.
Int Forum Allergy Rhinol
.
2014
;
4
(
Suppl 2
):
S79
83
. .
4.
Pecorari
G
,
Riva
G
,
Bianchi
FA
,
Cavallo
G
,
Revello
F
,
Bironzo
M
, et al.
The effect of closed septorhinoplasty on nasal functions and on external and internal nasal valves: a prospective study
.
Am J Rhinol Allergy
.
2017
;
31
(
5
):
323
7
. .
5.
Garzaro
M
,
Landolfo
V
,
Pezzoli
M
,
Defilippi
S
,
Campisi
P
,
Giordano
C
, et al.
Radiofrequency volume turbinate reduction versus partial turbinectomy: clinical and histological features
.
Am J Rhinol Allergy
.
2012
;
26
(
4
):
321
5
. .
6.
Lukka
VK
,
Jacob
TM
,
Jeyaseelan
V
,
Rupa
V
.
Do turbinate reduction procedures restore epithelial integrity in patients with turbinate hypertrophy secondary to allergic rhinitis? A histopathological study
.
Eur Arch Otorhinolaryngol
.
2018
;
275
(
6
):
1457
67
. .
7.
Neri
G
,
Cazzato
F
,
Mastronardi
V
,
Pugliese
M
,
Centurione
MA
,
Di Pietro
R
, et al.
Ultrastructural regenerating features of nasal mucosa following microdebrider-assisted turbinoplasty are related to clinical recovery
.
J Transl Med
.
2016
;
14
(
1
):
164
. .
8.
Gindros
G
,
Kantas
I
,
Balatsouras
DG
,
Kandiloros
D
,
Manthos
AK
,
Kaidoglou
A
.
Mucosal changes in chronic hypertrophic rhinitis after surgical turbinate reduction
.
Eur Arch Otorhinolaryngol
.
2009
;
266
(
9
):
1409
16
. .
9.
Olszewska
E
,
Sieskiewicz
A
,
Kasacka
I
,
Rogowski
M
,
Zukowska
M
,
Soroczyńska
J
, et al.
Cytology of nasal mucosa, olfactometry and rhinomanometry in patients after CO2 laser mucotomy in inferior turbinate hypertrophy
.
Folia Histochem Cytobiol
.
2010
;
48
(
2
):
217
21
. .
10.
Cassano
M
,
Granieri
C
,
Del Giudice
AM
,
Mora
F
,
Fiocca-Matthews
E
,
Cassano
P
.
Restoration of nasal cytology after endoscopic turbinoplasty versus laser-assisted turbinoplasty
.
Am J Rhinol Allergy
.
2010
;
24
(
4
):
310
4
. .
11.
Gelardi
M
,
Iannuzzi
L
,
Quaranta
N
,
Landi
M
,
Passalacqua
G
.
NASAL cytology: practical aspects and clinical relevance
.
Clin Exp Allergy
.
2016
;
46
(
6
):
785
92
. .
12.
Varghese
M
,
Glaum
MC
,
Lockey
RF
.
Drug-induced rhinitis
.
Clin Exp Allergy
.
2010
;
40
(
3
):
381
4
. .
13.
Riva
G
,
Franco
P
,
Provenzano
E
,
Arcadipane
F
,
Bartoli
C
,
Lava
P
, et al.
Radiation-induced rhinitis: cytological and olfactory changes
.
Am J Rhinol Allergy
.
2019
;
33
(
2
):
153
61
. .
14.
Riva
G
,
Boita
M
,
Ravera
M
,
Moretto
F
,
Badellino
S
,
Rampino
M
, et al.
Nasal cytological changes as late effects of radiotherapy for nasopharyngeal cancer
.
Am J Rhinol Allergy
.
2015
;
29
(
2
):
e41
5
. .
15.
Riva
G
,
Boita
M
,
Corvino
A
,
Sensini
M
,
Peruzzetto
D
,
Chiusa
L
, et al.
Nasal and tracheal cytological changes after total laryngectomy in long-term survivors
.
Ann Otol Rhinol Laryngol
.
2017
;
126
(
2
):
124
31
. .
16.
Bocchiotti
MA
,
Spaziante
L
,
Ruka
E
,
Pecorari
G
,
Garzaro
M
,
Riva
G
, et al.
Functional evaluation of the restored mucosa after nasal reconstruction with a forehead-galea flap
.
Eur J Plast Surg
.
2017
;
40
(
4
):
289
94
. .
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