Introduction: Tinnitus is a widely seen otological symptom that interferes with daily activities and causes discomfort. Tinnitus treatments can be classified into 4 main groups: pharmacological treatments, cognitive and behavioral therapy, psychological treatments, and combined treatment approaches made up of at least 2 of these 3 treatment methods. Objective: The aim of this study was to assess whether it would be possible to develop an individualized treatment method of tinnitus by application of a combined tinnitus signal and music during sleep. Methods: Forty-three ears of 30 patients who had subjective tinnitus were included. The patients were evaluated using Tinnitus Handicap Inventory, Visual Analogue Scale, and Beck Depression Inventory. The psychoacoustic parameters of tinnitus, such as tinnitus frequency and loudness, and minimal masking levels, were determined. The patients were asked to select musical melodies that they liked. The tinnitus frequency of each patient was taken as the central frequency according to ANSI 2004. All sound files were prepared as stereo channels, with 16-bit resolution and 44,100 Hz sampling rate. The root mean square power value of the music and the band noise’s average root mean square power value were equalized with the “Amplification” command, and 70% of the music and 30% of wide/narrow-band noise were mixed as a stereo channel by the “Mix Paste” command. The patients were instructed to listen to that individualized music/narrow-band noise (tinnitus signal) for 2 h during sleep for a duration of 6 months. Results: Tinnitus frequencies of the patients measured prior to treatment and at the second, fourth, and sixth months of follow-up were not significantly different. A statistically significant decrease was seen in tinnitus loudness, minimal masking levels, and residual inhibition during the follow-up. Tinnitus Handicap Inventory scores decreased significantly during follow-up, and the number of patients who complained of tinnitus decreased (p < 0.05). The Visual Analogue Scale scores significantly decreased during follow-up (p < 0.05). Beck Depression Inventory scores decreased significantly during follow-up (p < 0.05). Conclusion: Stimulation of the auditory and limbic systems during sleep by the tinnitus signal combined with individualized musical melodies seems an alternative, effective, and cheap method in the treatment of tinnitus.

1.
Møller
AR
.
Similarities between chronic pain and tinnitus
.
Am J Otol
.
1997
Sep
;
18
(
5
):
577
85
.
[PubMed]
0192-9763
2.
Kemp
DT
.
Stimulated acoustic emissions from within the human auditory system
.
J Acoust Soc Am
.
1978
Nov
;
64
(
5
):
1386
91
.
[PubMed]
0001-4966
3.
Adams
PF
,
Hendershot
GE
,
Marano
MA
;
Centers for Disease Control and Prevention/National Center for Health Statistics
.
Current estimates from the National Health Interview Survey, 1996
.
Vital Health Stat 10
.
1999
Oct
;(
200
):
1
203
.
[PubMed]
0083-1972
4.
Heller
AJ
.
Classification and epidemiology of tinnitus
.
Otolaryngol Clin North Am
.
2003
Apr
;
36
(
2
):
239
48
.
[PubMed]
0030-6665
5.
Jwp
H
, editor
.
Tinnitus
.
New York
:
Churchill Livingstone
;
1987
. pp.
1
19
.
6.
Jastreboff
PJ
,
Gray
WC
,
Gold
SL
.
Neurophysiological approach to tinnitus patients
.
Am J Otol
.
1996
Mar
;
17
(
2
):
236
40
.
[PubMed]
0192-9763
7.
Dallos
P
.
Cochlear physiology
.
Annu Rev Psychol
.
1981
;
32
(
1
):
153
90
.
[PubMed]
0066-4308
8.
Davies
E
,
Donaldson
I
.
Tinnitus, membrane stabilizers and taurine
.
Practitioner
.
1988
Oct
;
232
(
1456 ( Pt 2)
):
1139
.
[PubMed]
0032-6518
9.
DeBartolo
HM
 Jr
.
Zinc and diet for tinnitus
.
Am J Otol
.
1989
May
;
10
(
3
):
256
.
[PubMed]
0192-9763
10.
Dulon
D
,
Aran
JM
,
Schacht
J
.
Potassium-depolarization induces motility in isolated outer hair cells by an osmotic mechanism
.
Hear Res
.
1988
Feb-Mar
;
32
(
2-3
):
123
9
.
[PubMed]
0378-5955
11.
Mulders
WH
,
Leggett
K
,
Mendis
V
,
Tarawneh
H
,
Wong
JK
,
Rodger
J
.
Low-intensity repetitive transcranial magnetic stimulation over prefrontal cortex in an animal model alters activity in the auditory thalamus but does not affect behavioural measures of tinnitus
.
Exp Brain Res
.
2019
Apr
;
237
(
4
):
883
96
.
[PubMed]
0014-4819
12.
Melnick
W
.
American National Standard specifications for audiometers
.
ASHA
.
1971
Apr
;
13
(
4
):
203
6
.
[PubMed]
0001-2475
13.
Theodoroff
SM
,
McMillan
GP
,
Zaugg
TL
,
Cheslock
M
,
Roberts
C
,
Henry
JA
.
Randomized Controlled Trial of a Novel Device for Tinnitus Sound Therapy During Sleep
.
Am J Audiol
.
2017
Dec
;
26
(
4
):
543
54
.
[PubMed]
1059-0889
14.
Davis
AC
.
The prevalence of hearing impairment and reported hearing disability among adults in Great Britain
.
Int J Epidemiol
.
1989
Dec
;
18
(
4
):
911
7
.
[PubMed]
0300-5771
15.
Zenner
HP
.
K+-induced motility and depolarization of cochlear hair cells. Direct evidence for a new pathophysiological mechanism in Ménière’s disease
.
Arch Otorhinolaryngol
.
1986
;
243
(
2
):
108
11
.
[PubMed]
0302-9530
16.
Coles
RR
,
Hallam
RS
.
Tinnitus and its management
.
Br Med Bull
.
1987
Oct
;
43
(
4
):
983
98
.
[PubMed]
0007-1420
17.
Corey
DP
,
Hudspeth
AJ
.
Ionic basis of the receptor potential in a vertebrate hair cell
.
Nature
.
1979
Oct
;
281
(
5733
):
675
7
.
[PubMed]
0028-0836
18.
Durai
M
,
Kobayashi
K
,
Searchfield
GD
.
A feasibility study of predictable and unpredictable surf-like sounds for tinnitus therapy using personal music players
.
Int J Audiol
.
2018
Sep
;
57
(
9
):
707
13
.
[PubMed]
1499-2027
19.
Saunders
JC
,
Canlon
B
,
Flock
A
.
Changes in stereocilia micromechanics following overstimulation in metabolically blocked hair cells
.
Hear Res
.
1986
;
24
(
3
):
217
25
.
[PubMed]
0378-5955
20.
Czisch
M
,
Wetter
TC
,
Kaufmann
C
,
Pollmächer
T
,
Holsboer
F
,
Auer
DP
.
Altered processing of acoustic stimuli during sleep: reduced auditory activation and visual deactivation detected by a combined fMRI/EEG study
.
Neuroimage
.
2002
May
;
16
(
1
):
251
8
.
[PubMed]
1053-8119
21.
Morales-Cobas
G
,
Ferreira
MI
,
Velluti
RA
.
Firing of inferior colliculus neurons in response to low-frequency sound stimulation during sleep and waking
.
J Sleep Res
.
1995
Dec
;
4
(
4
):
242
51
.
[PubMed]
0962-1105
22.
Tilney
LG
,
Saunders
JC
.
Actin filaments, stereocilia, and hair cells of the bird cochlea. I. Length, number, width, and distribution of stereocilia of each hair cell are related to the position of the hair cell on the cochlea
.
J Cell Biol
.
1983
Mar
;
96
(
3
):
807
21
.
[PubMed]
0021-9525
23.
Tyler
RS
,
Conrad-Armes
D
.
Spontaneous acoustic cochlear emissions and sensorineural tinnitus
.
Br J Audiol
.
1982
Aug
;
16
(
3
):
193
4
.
[PubMed]
0300-5364
24.
Portas
CM
,
Krakow
K
,
Allen
P
,
Josephs
O
,
Armony
JL
,
Frith
CD
.
Auditory processing across the sleep-wake cycle: simultaneous EEG and fMRI monitoring in humans
.
Neuron
.
2000
Dec
;
28
(
3
):
991
9
.
[PubMed]
0896-6273
25.
Tonndorf
J
.
Acute cochlear disorders: the combination of hearing loss, recruitment, poor speech discrimination, and tinnitus
.
Ann Otol Rhinol Laryngol
.
1980
Jul-Aug
;
89
(
4 Pt 1
):
353
8
.
[PubMed]
0003-4894
26.
Tonndorf
J
.
The analogy between tinnitus and pain: a suggestion for a physiological basis of chronic tinnitus
.
Hear Res
.
1987
;
28
(
2-3
):
271
5
.
[PubMed]
0378-5955
27.
Pedemonte
M
,
Testa
M
,
Diaz
M
,
Suarez-Bagnasco
D.
The Impact of Sound on Electroencephalographic Waves during Sleep in Patients Suffering from Tinnitus.
Sleep science (Sao Paulo, Brazil).
2014
;7(3):143-51.
28.
Penner
MJ
,
Burns
EM
.
The dissociation of SOAEs and tinnitus
.
J Speech Hear Res
.
1987
Sep
;
30
(
3
):
396
403
.
[PubMed]
0022-4685
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