Abstract
Aims: To investigate the clinical features, treatment, and outcomes of laryngeal spindle cell carcinoma (SpCC). Methods: Between 2005 and 2014, patients from our hospital with SpCC of the larynx were retrospectively analyzed alongside patient data from the SEER database of America. Results: A total of 11 patients with SpCC of the larynx were diagnosed and underwent surgery in our hospital. All patients were male and all tumors were located in the glottis. The 3- and 5-year OS rates were both 54.5%. In the SEER database, 148 patients were diagnosed with SpCC of the larynx. The 3- and 5-year OS rates were 72.8 and 63.2%, respectively. According to the comparison of propensity score-matched analysis, the OS was longer in squamous cell carcinoma (SCC) of the larynx (p < 0.0001). Conclusion: SpCC of the larynx is rare and typically originates in the glottis. Its prognosis is worse than that of laryngeal SCC, and surgery is a reasonable treatment strategy.
References
1.
Marioni
G
, Marchese-Ragona
R
, Cartei
G
, Marchese
F
, Staffieri
A
. Current opinion in diagnosis and treatment of laryngeal carcinoma
. Cancer Treat Rev
. 2006
Nov
;32
(7
):504
–15
.
[PubMed]
0305-73722.
De Stefani
A
, Boffano
P
, Bongioannini
G
. Review of histologic and immunohistochemical features of spindle cell carcinomas (carcinosarcomas) of the larynx
. J Craniofac Surg
. 2014
Sep
;25
(5
):e430
–3
.
[PubMed]
1049-22753.
Rutt
AL
, Mintz
I
, Jackson-Menaldi
C
, Johns
M
, McHugh
JB
, Rubin
AD
. Spindle cell carcinoma of the larynx presenting as a vocal fold cyst
. J Voice
. 2014
Jul
;28
(4
):524.e9
–11
.
[PubMed]
0892-19974.
Zheng
Y
, Xiao
M
, Tang
J
. Clinicopathological and immunohistochemical analysis of spindle cell carcinoma of the larynx or hypopharynx: A report of three cases
. Oncol Lett
. 2014
Aug
;8
(2
):748
–52
.
[PubMed]
1792-10745.
Batsakis
JG
, Suarez
P
. Sarcomatoid carcinomas of the upper aerodigestive tracts
. Adv Anat Pathol
. 2000
Sep
;7
(5
):282
–93
.
[PubMed]
1072-41096.
Thompson
LD
, Wieneke
JA
, Miettinen
M
, Heffner
DK
. Spindle cell (sarcomatoid) carcinomas of the larynx: a clinicopathologic study of 187 cases
. Am J Surg Pathol
. 2002
Feb
;26
(2
):153
–70
.
[PubMed]
0147-51857.
Tulunay
O
, Küçük
B
, Yorulmaz
I
, Tulunay
EO
, Sanatipour
M
, Ayva
S
. Sarcomatoid carcinoma of the larynx: immunohistochemical analysis in two cases
. Otolaryngol Head Neck Surg
. 2006
Jun
;134
(6
):1057
–9
.
[PubMed]
0194-59988.
Spector
ME
, Wilson
KF
, Light
E
, McHugh
JB
, Bradford
CR
. Clinical and pathologic predictors of recurrence and survival in spindle cell squamous cell carcinoma
. Otolaryngol Head Neck Surg
. 2011
Aug
;145
(2
):242
–7
.
[PubMed]
0194-59989.
López
F
, Williams
MD
, Cardesa
A
, Hunt
JL
, Strojan
P
, Rinaldo
A
, et al. How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
Eur Arch Otorhinolaryngol
. 2017
Jul
;274
(7
):2709
–26
.
[PubMed]
0937-447710.
Boamah
H
, Ballard
B
. A case report of spindle cell (sarcomatoid) carcinoma of the larynx
. Case Rep Med
. 2012
;2012
:370204
.
[PubMed]
1687-962711.
Dubal
PM
, Marchiano
E
, Kam
D
, Dutta
R
, Kalyoussef
E
, Baredes
S
, et al. Laryngeal spindle cell carcinoma: A population-based analysis of incidence and survival
. Laryngoscope
. 2015
Dec
;125
(12
):2709
–14
.
[PubMed]
0023-852X12.
Roy
S
, Purgina
B
, Seethala
RR
. Spindle cell carcinoma of the larynx with rhabdomyoblastic heterologous element: a rare form of divergent differentiation
. Head Neck Pathol
. 2013
Sep
;7
(3
):263
–7
.
[PubMed]
1936-055X13.
Watson
RF
, Chernock
RD
, Wang
X
, Liu
W
, Ma
XJ
, Luo
Y
, et al. Spindle cell carcinomas of the head and neck rarely harbor transcriptionally-active human papillomavirus
. Head Neck Pathol
. 2013
Sep
;7
(3
):250
–7
.
[PubMed]
1936-055X14.
Choi
HR
, Sturgis
EM
, Rosenthal
DI
, Luna
MA
, Batsakis
JG
, El-Naggar
AK
. Sarcomatoid carcinoma of the head and neck: molecular evidence for evolution and progression from conventional squamous cell carcinomas
. Am J Surg Pathol
. 2003
Sep
;27
(9
):1216
–20
.
[PubMed]
0147-518515.
Marioni
G
, Bottin
R
, Staffieri
A
, Altavilla
G
. Spindle-cell tumours of the larynx: diagnostic pitfalls. A case report and review of the literature
. Acta Otolaryngol
. 2003
Jan
;123
(1
):86
–90
.
[PubMed]
0001-648916.
Viswanathan
S
, Rahman
K
, Pallavi
S
, Sachin
J
, Patil
A
, Chaturvedi
P
, et al. Sarcomatoid (spindle cell) carcinoma of the head and neck mucosal region: a clinicopathologic review of 103 cases from a tertiary referral cancer centre
. Head Neck Pathol
. 2010
Dec
;4
(4
):265
–75
.
[PubMed]
1936-055X17.
Zidar
N
, Boštjančič
E
, Gale
N
, Kojc
N
, Poljak
M
, Glavač
D
, et al. Down-regulation of microRNAs of the miR-200 family and miR-205, and an altered expression of classic and desmosomal cadherins in spindle cell carcinoma of the head and neck—hallmark of epithelial-mesenchymal transition
. Hum Pathol
. 2011
Apr
;42
(4
):482
–8
.
[PubMed]
0046-817718.
Miyahara
H
, Tsuruta
Y
, Yane
K
, Ogawa
Y
. Spindle cell carcinoma of the larynx
. Auris Nasus Larynx
. 2004
Jun
;31
(2
):177
–82
.
[PubMed]
0385-814619.
Gerry
D
, Fritsch
VA
, Lentsch
EJ
. Spindle cell carcinoma of the upper aerodigestive tract: an analysis of 341 cases with comparison to conventional squamous cell carcinoma
. Ann Otol Rhinol Laryngol
. 2014
Aug
;123
(8
):576
–83
.
[PubMed]
0003-489420.
Lewis
JE
, Olsen
KD
, Sebo
TJ
. Spindle cell carcinoma of the larynx: review of 26 cases including DNA content and immunohistochemistry
. Hum Pathol
. 1997
Jun
;28
(6
):664
–73
.
[PubMed]
0046-8177© 2020 S. Karger AG, Basel
2020
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.
