Clinical diagnoses of allergic airway disease need confirmation of a relevant sensitization to allergens. Serum-based component-resolved diagnosis has become increasingly popular and allows the precise assessment of specific IgE to molecular allergens. Molecular allergen diagnosis has improved our understanding of disease phenotypes in allergic patients, including cross-reactive patterns and food allergy. Beyond sensitization profiles, characterization of the (endo-)type and severity of a local allergic disease is useful for targeted therapy with biologics in advanced allergic airway disease. Surrogate markers of treatment efficacy are increasingly under validation. Prognostic and predictive biomarkers will represent a promising option for stratified prevention strategies.

1.
Bousquet J, et al: Allergic Rhinitis and Its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen). Allergy 2008;63(suppl 86):8-160.
2.
Schlaud M, Atzpodien K, Thierfelder W: Allergic diseases. Results from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) (in German). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2007;50:701-710.
3.
Shaaban R, et al: Rhinitis and onset of asthma: a longitudinal population-based study. Lancet 2008;372:1049-1057.
4.
Walker S, et al: Seasonal allergic rhinitis is associated with a detrimental effect on examination performance in United Kingdom teenagers: case-control study. J Allergy Clin Immunol 2007;120:381-387.
5.
Thompson AK, Juniper E, Meltzer EO: Quality of life in patients with allergic rhinitis. Ann Allergy Asthma Immunol 2000;85:338-347; quiz 347-348.
6.
Vuurman EF, et al: Allergic rhinitis is a risk factor for traffic safety. Allergy 2014;69:906-912.
7.
Bergmann KC, Heinrich J, Niemann H: Current status of allergy prevalence in Germany: position paper of the Environmental Medicine Commission of the Robert Koch Institute. Allergo J Int 2016;25:6-10.
8.
Nwaru BI, et al: The epidemiology of food allergy in Europe: a systematic review and meta-analysis. Allergy 2014;69:62-75.
9.
Du Toit G, et al: Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med 2015;372:803-813.
10.
Du Toit G, et al: Effect of avoidance on peanut allergy after early peanut consumption. N Engl J Med 2016;374:1435-1443.
11.
Panesar SS, et al: The epidemiology of anaphylaxis in Europe: a systematic review. Allergy 2013;68:1353-1361.
12.
Biermann J, et al: Allergische Erkrankungen der Atemwege - Ergebnisse einer umfassenden Patientenkohorte in der deutschen gesetzlichen Krankenversicherung. Allergo J 2013;22:363-373.
13.
Kleine-Tebbe J, Matricardi PM, Hamilton RG: Allergy work-up including component-resolved diagnosis: how to make allergen-specific immunotherapy more specific. Immunol Allergy Clin North Am 2016;36:191-203.
14.
Rueff F, et al: Skin tests for diagnostics of allergic immediate-type reactions. Guideline of the German Society for Allergology and Clinical Immunology. Pneumologie 2011;65:484-495.
15.
Bousquet J, et al: Practical guide to skin prick tests in allergy to aeroallergens. Allergy 2012;67:18-24.
16.
Johansson SG: The History of IgE: from discovery to 2010. Curr Allergy Asthma Rep 2011;11:173-177.
17.
Matricardi PM, et al: EAACI molecular allergology user's guide. Pediatr Allergy Immunol 2016;27(suppl 23): 1-250.
18.
Bousquet J, et al: Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs. J Allergy Clin Immunol 2012;130:1049-1062.
19.
Kleine-Tebbe J, Ollert M, Jakob T: Molekulare Allergologie: Nomenklatur, Proteinfamilien, Datenbanken und potentieller Nutzen. Allergo J 2010;19:390-394.
20.
Worm M, et al: Food allergies resulting from immunological cross-reactivity with inhalant allergens: guidelines from the German Society for Allergology and Clinical Immunology (DGAKI), the German Dermatology Society (DDG), the Association of German Allergologists (AeDA) and the Society for Pediatric Allergology and Environmental Medicine (GPA). Allergo J Int 2014;23:1-16.
21.
Chaker AM, Klimek L: Individualized, personalized and stratified medicine: a challenge for allergology in ENT? (in German). HNO 2015;63:334-342.
22.
Lazic N, et al: Multiple atopy phenotypes and their associations with asthma: similar findings from two birth cohorts. Allergy 2013;68:764-770.
23.
Kurukulaaratchy RJ, et al: Identifying the heterogeneity of young adult rhinitis through cluster analysis in the Isle of Wight birth cohort. J Allergy Clin Immunol 2015;135:143-150.
24.
Shamji MH, et al: Functional rather than immunoreactive levels of IgG4 correlate closely with clinical response to grass pollen immunotherapy. Allergy 2012;67:217-226.
25.
Di Lorenzo G, et al: Evaluation of serum s-IgE/total IgE ratio in predicting clinical response to allergen-specific immunotherapy. J Allergy Clin Immunol 2009;123:1103-1110, 1110.e1-4.
26.
Lima MT, et al: Grass pollen sublingual immunotherapy for seasonal rhinoconjunctivitis: a randomized controlled trial. Clin Exp Allergy 2002;32:507-514.
27.
Chaker AM, et al: Short-term subcutaneous grass pollen immunotherapy under the umbrella of anti-IL-4: a randomized controlled trial. J Allergy Clin Immunol 2016;137:452-461.e9.
28.
Shamji MH, et al: Basophil expression of diamine oxidase: a novel biomarker of allergen immunotherapy response. J Allergy Clin Immunol 2015;135:913-921.e9.
29.
Zissler UM, et al: Current and future biomarkers in allergic asthma. Allergy 2016;71:475-494.
30.
Corren J, et al: Lebrikizumab treatment in adults with asthma. N Engl J Med 2011;365:1088-1098.
31.
Hanania NA, et al: Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials. Lancet Respir Med 2016;4:781-796.
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