Objectives: To identify the effects of laryngopharyngeal reflux (LPR)-related laryngeal findings on objective voice parameters. Methods: Two hundred and thirty patients clinically diagnosed as having LPR and 48 healthy controls were included. The reflux finding score was determined for each subject via videolaryngoscopy. The acoustic parameters evaluated were jitter, shimmer, noise-to-harmonic ratio and Voice Turbulence Index (VTI). Results: Shimmer and VTI showed statistically significant differences between the LPR and control groups among males (p < 0.05). For females, all of the 4 acoustic voice parameters were significantly different between the two groups (p < 0.05). Erythema/hyperemia was found to affect the highest number of voice parameters. VTI was found to be affected by the highest number of laryngeal findings. Conclusion: Objective voice changes were documented in LPR patients, with VTI being the most affected parameter, and therefore it should be considered in the acoustic analysis of patients with LPR in addition to the conventional parameters. With hyperemia in the first rank, ventricular obliteration, pseudosulcus and vocal fold edema are found to have an impact on voice, suggesting that these should be concentrated on in the diagnosis and follow-up of LPR patients with voice disorders.

Keywords:
Acoustic analysis, Jitter, Shimmer, Laryngopharyngeal reflux, Noise-to-harmonic ratio, Voice turbulence index, Reflux finding score
1.
Ali Mel-S: Laryngopharyngeal reflux: diagnosis and treatment of a controversial disease. Curr Opin Allergy Clin Immunol 2008;8:28–33.
2.
Bove MJ, Rosen C: Diagnosis and management of laryngopharyngeal reflux disease. Curr Opin Otolaryngol Head Neck Surg 2006;14:116–123.
3.
Belafsky PC, Postma GN, Koufman JA: The validity and reliability of reflux finding score (RFS). Laryngoscope 2001;111:1313–1317.
4.
Belafsky PC, Postma GN, Koufman JA: Validity and reliability of the reflux symptom index (RSI). J Voice 2002;16:274–277.
5.
Ogut F, Ersin S, Engin EZ, Kirazli T, Midilli R, Unsal G, Bor S: The effect of laparoscopic Nissen fundoplication on laryngeal findings and voice quality. Surg Endosc 2007;21:549–554.
6.
Hicks DM, Ours TM, Abelson TI, Vaezi MF, Richter JE: The prevalence of hypopharynx findings associated with gastroesophageal reflux in normal volunteers. J Voice 2002;16:564–579.
7.
Ross JA, Noordzji JP, Woo P: Voice disorders in patients with suspected laryngo-pharyngeal reflux disease. J Voice 1998;12:84–88.
8.
Pribuisiene R, Uloza V, Kupcinskas L, Jonaitis L: Perceptual and acoustic characteristics of voice changes in reflux laryngitis patients. J Voice 2006;20:128–136.
9.
Oguz H, Tarhan E, Korkmaz M, Yilmaz U, Safak MA, Demirci M, Ozluoglu LN: Acoustic analysis findings in objective laryngopharyngeal reflux patients. J Voice 2007;21:203–210.
10.
Selby JC, Gilbert HR, Lerman JW: Perceptual and acoustic evaluation of individuals with laryngopharyngeal reflux pre- and post-treatment. J Voice 2003;17:557–570.
11.
Hamdan AL, Sharara AI, Younes A, Fuleihan N: Effect of aggressive therapy on laryngeal symptoms and voice characteristics in patients with gastroesophageal reflux. Acta Otolaryngol 2001;121:868–872.
12.
Kay Elemetrics Corp: Multi-Dimensional Voice Program (MDVP) Model 5105: Software Instruction Manual. Lincoln Park, Kay Elemetrics Corp, 1999.
13.
Wolfe V, Martin D: Acoustic correlates of dysphonia: type and severity. J Commun Disord 1997;30:403–415.
14.
Bhuta T, Patrick L, Garnett JD: Perceptual evaluation of voice quality and its correlation with acoustic measurements. J Voice 2004;18:299–304.
© 2012 S. Karger AG, Basel
2012
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