A rare case of malignant melanoma of the base of the tongue in a 65-year-old Japanese woman is described. The primary and metastatic tumors were treated by surgery, chemohormone and immunotherapy. There was no recurrence for 5 years after the initial diagnosis. Electron microscopy suggested that the melanosomes of the melanoma cells in the cervical lymph nodes were less mature than those in the primary melanoma cells; melanosome immaturity was consistent with a more aggressive quality.

Keywords:
Malignant melanoma, Base of tongue, Neck metastasis, Surgery, Interferon, Chemohormone therapy, Electron microscopy
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© 2000 S. Karger AG, Basel
2000
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