Aspirin and other salicylates influence otoacoustic emissions (OAEs), but changes in transiently evoked OAEs (TEOAEs) following aspirin intake have not been studied experimentally. We examined the changes in TEOAEs, together with auditory brainstem responses (ABRs), in guinea pigs before and after the intravenous injection of aspirin (100 and 400 mg/kg). TEOAE power decreased slowly after the injection in a dose-dependent manner. Mean minimal values were detected 20 min after the injection of 100 mg/kg, and 40 min after the injection of 400 mg/kg. TEOAE power recovered slowly. These changes were paralleled by shifts in ABR thresholds. The magnitude of the decrease in the frequency components in the TEOAE frequency power spectrum was similar. In one guinea pig, TEOAE power returned to the pretreatment level 7 h after the injection. Findings support the results of in vitro studies that salicylates affect electromotility in isolated outer hair cells from guinea pig cochlea.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.