Treatment of pregnant Sprague-Dawley rats with etretinate or retinoic acid on pregnancy days 8.5–9.0 resulted in craniofacial defects in all embryos. A morphological investigation of the malformations occurring in the nasal region is described. The external nose was deformed with a depressed nasal bridge and pronounced hump. Fusion between nasal processes was defective, resulting in fistulas and clefts. The nasal septal cartilage was reduced in size, the paranasal cartilage was missing, the parietothecal cartilage was deformed and the paraseptal cartilage was dislocated. Aberrant vessels were seen on the external nose in combination with underdevelopment of the vibrissae. The distance between the outer nasal pores was reduced after administration of retinoids.

Keywords:
Etretinate, Retinoic acid, Teratogenicity, Nasal malformations, Histology, Scanning electron microscopy
This content is only available via PDF.
© 1990 S. Karger AG, Basel
1990
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.