By using well-defined monoclonal antibodies, the distribution of synaptophysin and the glycoprotein Egp-34, the first of its kind, was analyzed immunohistochemically in the fetal and the adult human inner ear. In fetal labyrinths, a distinct immunoreactivity for synaptophysin occurred in the apical region of both outer and inner hair cells as well as in nerve terminals adjacent to both cochlear and vestibular hair cells. In adult hair cells, immunoreactivity was found throughout the cytoplasm. Synaptophysin may act as an important calcium binding protein in the sensory transduction of hair cells. A selective expression of Egp-34 was found in the area of marginal and intermediate cell infoldings in the stria vascularis. A similar localization pattern was found for a number of membrane transport enzymes. The glycoprotein Egp-34 is probably of importance for the active mechanisms regulating the homeostasis of endolymph.

Keywords:
Inner ear, Synaptophysin, HEA-125, Immunomorphology
This content is only available via PDF.
© 1989 S. Karger AG, Basel
1989
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.