Evidence is presented that, in contrast to the traditional view, a large proportion of the proteins of the tectorial membrane (TM) consists of collagen, primarily type II: (1) characteristic amino acid composition of TM, including high levels of glycine, hydroxyproline and hydroxylysine; (2) comigration of the main TM protein with appropriate collagen standards in two-dimensional gel electrophoresis; (3) digestion of the main TM protein band following treatment with bacterial collagenase; (4) one- and two-dimensional peptide mapping of cyanogen bromide digests of the TM exhibits patterns characteristic for collagen type II.

Keywords:
Cochlea, Tectorial membrane, Collagen, Guinea pig
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© 1986 S. Karger AG, Basel
1986
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