The values of total spinal protein in cerebrospinal fluid (CSF), used as normal material, from 98 persons are presented. These values showed that the previously used reference limits (0.20–0.40 g/l) for total protein in CSF were too low, and consequently the new reference values 0.20–0.85 g/l are used. 77 patients with surgically verified acoustic neuromas had total protein determined in CSF prior to operation, and 63% of patients with tumours less than 25 mm in diameter had normal total protein values, while only 3% of patients with tumours larger than 25 mm had normal values. Since the large tumours can be easily diagnosed by the non-invasive computer tomography, it is concluded that CSF total protein determination is only of limited value in the search for acoustic neuromas. A more quantitated examination of CSF proteins (albumin, alpla2-macroglobulin, IgA, IgG and IgM) showed significantly increased values among the tumour patients, but the findings were not of any significant clinical value in the diagnosis of tumours.

Keywords:
Total spinal protein, Acoustic neuroma, Normal values, Albumin, Immunoglobulins
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© 1982 S. Karger AG, Basel
1982
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