... under the following conditions: (1) after intravenous injection of propofol plus ketamine; (2) during inhalation of isoflurane, and (3) 2 h after topical administration of bimatoprost or (4) timolol. Propofol/ketamine and isoflurane induced significant decreases in the IOP. The pulsation...

...Norihiko Kitaya; Akitoshi Yoshida; Satoshi Ishiko; Fumihiko Mori; Tohru Abiko; Hironobu Ogasawara; Yuji Kato; Taiji Nagaoka The effects of topically applied timolol (a nonselective beta-blocker) and UF-021 (a prostaglandin-related compound) on pulsatile ocular blood flow (POBF) were investigated...

...T. Kodama; V.N. Reddy; F.J. Macri The effects of pilocarpine, isoproterenol, epinephrine, timolol, acetazolamide, ouabain, and dinitrophenol on aqueous humor production were investigated in enucleated rabbit eye. The metabolic inhibitors ouabain and dinitrophenol at a concentration of 10 –– 5 M...

...P. Vareilles; V.J. Lotti The effects of timolol and several reference agents upon intraocular pressure (IOP), outflow facility and aqueous humor formation, were investigated in rabbits. Consistent with their proposed mechanisms of action, norepinephrine and epinephrine (1% topically) lowered IOP...

...K. Watanabe; G.C.Y. Chiou The effect of timolol on the active transport system in the iris root-ciliary body of rabbits was studied to elucidate the action mechanism of timolol. Neither Na + -K + -adenosine triphosphatase (ATPase) nor Mg ++ -ATPase was inhibited by timolol at 1 × 10 ––4 M...

... induced dopaminergic responses. Timolol produced similar effects as reserpine, which supports the idea that timolol reduces aqueous humor formation through elimination of dopaminergic function and reduction of blood flow in the ciliary body. 22 11 1982 28 02 1983 4 12 2009 © 1983 S...

...L. Missotten; M. Goethals Timolol, applied as an 0.5% ophthalmic solution, reduces the light insensitive component of the electro-oculogram by about 40%. This observation suggests that the ocular hypotensive effect of this drug is due to a reduction of the active transport mechanism of the ciliary...

... to a benzalkonium-chloride-containing antiglaucoma drug. Methods: Timolol preserved with 0.01% benzalkonium chloride solution was applied b.i.d. in 1 eye of 10 rabbits for 56 days. Unpreserved timolol solution was used as control. Ocular surface changes were assessed weekly combining clinical examinations, in vivo...