... often appears in the absence of drusen but is rather accompanied by pigmentary abnormality. Recently, shallow irregular retinal pigment epithelium (RPE) elevations (SIRE) have been shown as a sign of subclinical nonexudative macular neovascularization. In this study, we aimed to investigate...

...Noemi Eiro; Juan Sendon-Lago; Sandra Cid; Jorge Saa; Nagore de Pablo; Belen Vega; Maria A. Bermudez; Roman Perez-Fernandez; Francisco J. Vizoso Introduction: Retinal homeostasis is essential to avoid retinal pigment epithelium (RPE) damage resulting in photoreceptor death and blindness. Mesenchymal...

... porcine retinal pigment epithelium (RPE) cells in first passage and in ARPE-19 cell line. Cells were treated with 250 µg/mL bevacizumab, aflibercept, or, as a non-VEGF inhibiting antibody, rituximab once a week for 1 day, 7 days, 4, and 12 weeks. Cell survival was evaluated with methyl thiazolyl...

... distribution in retinal pigment epithelium (RPE). RPE was detected with higher contrast in the PAM B-scan image than optical coherence tomography (OCT). Additionally, the CNV lesion was present with multiple PA signal intensities which distinctly characterized the location and area of CNV as found in fundus...

..., instructions or products referred to in the content or advertisements. Curcumin Nano-curcumin Proteasome Retinal pigment epithelium Curcumin (1, 7-bis-[4-hydroxy-3-methoxyphenyl]-1, 6-heptadiene-3,5-dione) is the orange and water-insoluble pigment extract of turmeric, the rhizome of Curcuma...

...: The expression of >11,000 genes was analysed by means of a microarray in cells cultured from 2 late-stage CNV membranes compared to primary human retinal pigment epithelium (RPE) and ARPE-19 cells. A pathway analysis was performed to identify gene expression patterns associated with exudative AMD. Results...

... antibodies or additional triggers to reproduce the enhancement of cytokine production and to get insight into possibly involved intracellular signalling pathways by examination of the transcription factor NF-κB. Inflammation Complement Retinal pigment epithelium © 2015 S. Karger AG, Basel...

...Jingyang Feng; Xunjie Chen; Xiangjun Sun; Fenghua Wang; Xiaodong Sun Aims: Age-related lipofuscin N-retinylidene-N-retinylethanolamine (A2E) accumulated in human retinal pigment epithelium (RPE) cells confers susceptibility to blue light-mediated damage, which represents one pathogenesis of age...

...Shani Golan; Ran Levi; Michal Entin-Meer; Adiel Barak Purpose: To determine the effect of the most commonly used vital dyes in vitrectomy [trypan blue at 0.15% concentration and indocyanine green (ICG) at 0.5% concentration] on the viability of human retinal pigment epithelium (RPE) cell lines...

... to in the content or advertisements. Age-related macular degeneration Factor H Interleukin In situ hybridization Retinal cell culture Retinal pigment epithelium Age-related macular degeneration (AMD) is the leading cause of legal blindness in the elderly in the Western world. The role...

...Antonis Koutsonas; Doerthe Carstesen; Corinna Henkel; Peter Walter; Gabriele Thumann; Andreas W.A. Weinberger Objective: Changes in fundus autofluorescence (AF) are observed in various retinal disorders. Lipofuscin accumulation within the retinal pigment epithelium (RPE) is a source of fundus AF...

... for the implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium (RPE) cells into the subretinal space of retina-degenerate Royal College of Surgeon (RCS) rats. Methods: A platform device was used for the implantation of 4-µm-thick parylene substrates containing a monolayer of human...

...Fabian Thieltges; Boris V. Stanzel; Zengping Liu; Frank G. Holz Background: To evaluate the influence of surface topography on the proliferation of the retinal pigment epithelium (RPE) by comparing nanofibrillar and smooth substrates. Methods: Electrospun polyamide nanofibers (EPN...

...Alexa Klettner; Friederike Möhle; Ralph Lucius; Johann Roider The retinal pigment epithelium (RPE) is the most active phagocyte in the human body, and this function is indispensable for vision. In this study, we introduce an easy and inexpensive way to quantify RPE phagocytosis by opsonizing FITC...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Retinal pigment epithelium Repair process Regenerated cells Macrophage-like RPE cells Ophthalmic, Research Original Paper Ophthalmic Res...

...-associated virus Retina Retinal pigment epithelium Peripherin/ rds Mouse Viral vector Ophthalmie, Research Ophthalmic Res 1997:29:261-268 MB. Reichela - b R.R. Alib D.M. Himtb S S. Bhaüacharyab Gene Therapy for Retinal Degeneration a Department of Ophthalmology, Faculty of Medicine. University...

...T. Toimela; H. Tähti; L. Salminen The retinal pigment epithelium (RPE) removes the outer segments of photoreceptor cells by phagocytosis. We studied the effects of tamoxifen and chloroquine on the activity of the lysosomal enzymes N-acetyl-β-glucosaminidase and cathepsin D in RPE in vitro...

.... Neuronal cell death occurred at all ages and was more pronounced in albino rats. Moreover, in albino rats, cones were more resistant than rods to destruction by age and ambient light. As age-related ultrastructural changes in the retinal pigment epithelium (RPE) (1) a substantial accumulation of lipo...

... and new blood vessels were permeable to fluorescein and peroxidase, but not to catalase. The regenerating retinal pigment epithelium gradually reformed a continuous sheet of cells covering all small laser sites and the periphery of large lesions. Zonulae occludens between the regenerated cells restored...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Ascorbate Dehydroascorbate Sodium Retinal pigment epithelium Active transport Oxidative reduction Original Paper Ophthalmic Res 1993;25:100...