...Ana Paula Resende; Berta São Braz; Esmeralda Delgado Purpose: The present study aimed to determine whether the subconjunctival administration of recombinant human erythropoietin (rHuEPO) reached the retina in glaucoma conditions. After subconjunctival rHuEPO administration, in a rat glaucoma model...

... of N-methyl D -aspartate (NMDA)-induced retinal ganglion cell (RGC) damage in juvenile and young adult rats. Methods: Juvenile (30-35 days old) and young adult (56-70 days old) female Brown Norway rats were fed the KD for 21 days; rats exposed to a standard rodent diet (SRD) served as controls...

...Franziska Drechsler; Patricia Köferl; Margrit Hollborn; Peter Wiedemann; Andreas Bringmann; Leon Kohen; Matus Rehak Purpose: To determine the effect of intravitreal bevacizumab and anti-vascular endothelial growth factor (VEGF) antibodies on the gene expression in the neural retina in a rat model...

... in the ganglion cell layer. Methods: Wister rats were fixed by perfusion with 5% glutaraldehyde. Paraffin sections of the retina were immunohistochemically double-labeled using D -aspartate and glutamate or γ-aminobutyric acid antibodies. After labeling the whole-mount retina by D -aspartate, the cell densities...

...A. Micali; A. Pisani; D. Puzzolo; R. Spinella; A. Roszkowska; P. Aragona Aim: To study the conjunctival development in hypothyroid genetically epilepsy-prone rats (GEPRs) with serum T3 and T4 significantly lower than in normal rats. Methods: A structural, ultrastructural and histochemical study...

... for calpains I and II in young rat lenses. An in vitro model of crystallin precipitation was used to assess the ability of calpain I to induce hydrolysis and precipitation of crystallins. We found that incubation of crystallins with purified calpain I was indeed a powerful inducer of crystallin precipitation...

...John L. Hess; Kenneth P. Mitton; G.E. Bunce Selenite treatment of the preweanling rat stabilized the transparency of the lens nucleus to decreasing temperature. Hence, we compared properties of the cortex and nucleus from lenses of selenite-treated and age-matched control rats. A subcutaneous dose...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Radiation cataract Cataract assessment Scheimpflug imaging Lens transparency Rat Ionizing radiation Heavy ions...

...Toshinori Murata; Tatsuro Ishibashi; Hajime Inomata A consistent animal model of intraocular neovascularization was developed in the rat. A vitreous hemorrhage was induced by an experimental incision through the pars plana in the right eye of 24 rats. One month after the incision, 21 eyes produced...

...M.G. Rittig; K. Licht; R.H.W. Funk The ciliary processes (CPs) in the rat were investigated for the presence of neuropeptide Y (NPY)-like immunoreactivity and for histofluorescence indicating catecholamine (CAM)-ergic innervation in the rat, rabbit and cynomolgus monkey. Special attention was paid...

...Reiko Hirai; Nobuaki Tamamaki; Kaitiro Hukami; Yoshiaki Nojyo Different patterns of distribution of chemically different nerve fibers in the rat iris were studied by immunoelectron microscopy. The iris was immunostained either singly for tyrosine hydroxylase (TH), or doubly for substance P (SP...

...R.H.W. Funk In the cynomolgus monkey, rabbit and rat the architecture of the pars plana vasculature was investigated using scanning electron micrographs of resin casts. The most complex vessel architecture was found in the cynomolgus monkey. Here, the pars plana venules have affluxes from...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Naproxen Cataract Selenium Glutathione Malonaldehyde Protein Rat Lens wet weight Water content Original Paper...

...Kenji Sakagami; Hiroaki Naka; Atsushi Hayashi; Motohiro Kamei; Tetsuo Sasabe; Yasuo Tano A new, simple method for isolating retinal pigment epithelial (RPE) cells from rat eyeballs was developed: incubation of the eyeballs in 0.1% proteinase K solution. This method yielded an average of 4 × 10 4...

...Imran Ahmed Bhutto; Tsugio Amemiya Retinal vasculature changes during aging in normal Wistar Kyoto rats maintained to longevity without known diseases were studied by corrosion casts and scanning electron microscopy (SEM). Six-month-old rat retina showed regular running and arrangement of retinal...

...Masami Oguni; Osamu Tanaka; Haruko Tamura; Haruo Shinohara; Kanefusa Kato; Tomoichi Setogawa The localization of copper-zinc and manganese superoxide dismutase (SOD) in the developing rat retina was studied immunohistochemically and immunochemically. Immunoreactivity to Cu/Zn SOD was observed...

...Julie A. Johnson; Joseph P. Grande; Patrick C. Roche; Jean Campbell; Rajiv Kumar Epitopes of the calcitriol receptor, the ATP-dependent plasma membrane calcium pump (PMCA) and the 28-kD vitamin-D-dependent Ca-binding protein (calbindin-D 28k ) were detected in sections of the albino rat eye using...

...Ralph Michael; Per G. Söderberg; Enping Chen The long-term development of lens opacities after short-term exposure to ultraviolet radiation (UVR) was determined. Altogether, 200 Sprague-Dawley rats received unilaterally 5 or 20 kJ/m 2 UVR (λ max = 300 nm, λ 0.5 = 10 nm) in vivo, during 15 min. At 1...

...Stefan D. Trocmé; C. Mitchell Gilbert; Mathea R. Allansmith; Kurt J. Bloch; Mark B. Abelson Cellular events in the rat conjunctiva were studied at 1 6 and 24 h following the topical application of leukotriene B 4 . A significant increase was noted in the number of eosinophils (p < 0.01...

...Otto Hockwin; Peter Müller; Jan Krolczyk; Bette A. McCue; Philip R. Mayer Investigations on the disposition of the highly effective aldose reductase inhibitor ALO 1576 were carried out in pigmented rats after oral dosing and topical administration of a 0.1 % ophthalmic suspension by means...