... of thalidomide, on inflammatory corneal angiogenesis. Methods: Eighteen rabbits were submitted to an alkaline cauterization in the right cornea. The animals were randomly allocated to three groups: vehicle, dexamethasone and LASSBio-596. Drugs were administered by eyedrops 3 times a day for 21 days. Evaluations...

... limited comparative data are available on the effect of encapsulated drugs on intraocular pressure (IOP) after filtering surgery. Therefore we have studied the effect on IOP of liposomes, nanospheres and a solution of mitoxantrone (MTO), a well-known antimitotic, in rabbits before and after sclerectomy...

...M. Reim; S. Busse; M. Leber; C. Schulz Ten rabbits with the right eye burnt by 1 N NaOH were treated 5 times daily with epidermal growth factor (EGF) eyedrops or placebo. The epithelium seemed to heal better under EGF treatment than with placebo. Also, ulceration and secondary calcification...

...D.F. Woodward; L.S. Williams; J. Chen A comparison of the effects of the major metabolites of prostaglandins E 2 , F 2α , and D 2 (PGE 2 , PGF 2α and PGD 2 ) on rabbit intraocular pressure (IOP) revealed differences in potency relative to each other and the parent prostanoid. 15-Keto PGF 2α...

...Jeff Payne; Tracey M. Slagle; Lisa T. Cheeks; Keith Green We determined the effects of either topical or systemic calcium channel antagonists on rabbit intraocular pressure (IOP). Topical nifedipine, verapamil or diltiazem had no significant effect on IOP. Intravenous verapamil and nifedipine...

...L. Krejci The pH changes of the tear film, thecorneal surface and corneal stroma in rabbit eyes with normal and high intraocular pressure (IOP) associated with experimental trauma were followed. Highly significant differences were found between the pH of intact and injured corneas in eyes...

...Tseggai Gherezghiher; Michael C. Koss An assay technique that utilizes liquid chromatrography with electrochemical detection to determine the norepinephrine (NE) concentration of the rabbit aqueous humor (AH) and iris-ciliary body (ICB) is discussed. NE concentration was monitored in control...

...P. Vareilles; V.J. Lotti The effects of timolol and several reference agents upon intraocular pressure (IOP), outflow facility and aqueous humor formation, were investigated in rabbits. Consistent with their proposed mechanisms of action, norepinephrine and epinephrine (1% topically) lowered IOP...

...J.A. Oosterhuis; J. Versteeg; P.J. Kruit; B.H. Postma In experimental herpetic keratitis in rabbits, aciclovir proved to have a high antiviral activity, superior to that of idoxuridine. Viral encephalitis was partly prevented by local treatment and fully by systemic treatment with aciclovir. 25...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Vasoconstrictor Ocular decongestant Naphazoline HCl Rabbits Area above the curve Grading system Ophthalmic Res. 7...

...U. Mester; H.J. Stein; H.-R. Koch Acute reversible lens opacities were induced in rabbits by intraocular irrigation with I and 5% acetylcholine solutions. Determinations of fresh weights and dry weights in removed lenses, as compared to solvent-treated and untreated controls, showed a significant...

...Linghui Qu; Liangmao Li; Hanping Xie Background: Little is known about the ocular penetration following intrastromal or intracameral injection of amphotericin B (AMB), the current drug of choice in fungal keratitis. Concentrations of AMB were investigated in the cornea and aqueous humor of rabbits...

..., the aim of the study was to evaluate whether adding dexamethasone to NAC could reduce the side effects of the two drugs. In this study, experimental corneal wounds were created surgically, up to the depth of one half of the stroma in the center of both eyes of all rabbits. The left eyes were treated...

... experimental implantation data regarding cellular reaction on the anterior surface of IOLs. Methods: Thirteen adult albino rabbits had phacoemulsification/aspiration of the crystalline lens followed by implantation of a posterior chamber IOL in each eye. Three types of IOLs were studied: Hydroview ® (Bausch...

...Susi Burgalassi; Luana Panichi; Patrizia Chetoni; M. Fabrizio Saettone; Enrico Boldrini The present paper is concerned with the development of a simple dry eye model in the rabbit, induced by daily repeated instillations of 1.0% atropine sulphate. The evolution of the dry eye syndrome...