... in rabbits. Methods: IOP was measured by a pneumatonometer before and after intracameral injection of Hsp90 inhibitors. The aqueous flow rate was measured by fluorophotometry. Trans-epithelial electrical resistance was measured in primary human trabecular meshwork cells. Results: 17-AAG, a specific Hsp90...

... underlying its ability to reduce IOP remain unclear. We therefore investigated the morphological changes and mechanisms of IOP reduction after MP-TSCPC. Methods: The right eyes of 4 pigmented rabbits were treated with MP-TSCPC with power setting corresponding to those used in glaucoma patients (1 power...

... vein endothelial cells (HUVECs) was assessed by an XTT assay [2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)- 2 H-tetrazolium-5-carboxanilide]. A basic fibroblast growth factor-impregnated gelatin hydrogel sheet was implanted into the rabbit cornea to induce corneal neovascularization. Immediately...

...Hülya Yazıcı; Gökhan Gürelik; Fulya Yaylacıoğlu Tuncay; Pınar Uyar Göçün Purpose: To examine whether ciliary body transplantation is applicable, the graft is viable and the localization of the graft material affects graft survival. Methods: Fifteen female New Zealand white rabbits were used. Three...

... difficult. Mice and rats provide genetically controlled models for investigations. Pigs, dogs and cats represent good large-size animal models, while rabbits are one of the most used species for retinal toxicity evaluations. Various laboratory methods were identified, including light microscopy, electron...

...-kylindoles and the arachidonylethanolamides (the endogenous ligands). We examined the IOP effect in normotensive rabbits after systemic administration of an aminoalkylindole, WIN-55,212-2, and of (R)-(+)-methanandamide, a hydrolysis-resistant endogenous ligand derivative. The decrease in IOP for 6 animals...

...Leon Kohen; Volker Enzmann; Frank Faude; Peter Wiedemann Purpose: The role of activated retinal pigment epithelium (RPE) cells was investigated in the rejection after subretinal transplantation. Methods: RPE cells from 7 pigmented rabbits were separated and evaluated regarding their MHC class II...

...M.G. Rittig; K. Licht; R.H.W. Funk The ciliary processes (CPs) in the rat were investigated for the presence of neuropeptide Y (NPY)-like immunoreactivity and for histofluorescence indicating catecholamine (CAM)-ergic innervation in the rat, rabbit and cynomolgus monkey. Special attention was paid...

...R.H.W. Funk In the cynomolgus monkey, rabbit and rat the architecture of the pars plana vasculature was investigated using scanning electron micrographs of resin casts. The most complex vessel architecture was found in the cynomolgus monkey. Here, the pars plana venules have affluxes from...

.... A quantitative model of fibrin deposition in the rabbit anterior chamber was used to assess the efficacy of Suleparoide I.N.N. (HHS-5) in preventing fibrin formation and in promoting the clearance of fibrinous membranes. Citrated human plasma was injected intracamerally after paracentesis to induce the formation...

...K. Mochizuki; Y. Yamashita; M. Torisaki; M. Komatsu; T. Tanahashi; K. Kawasaki The concentration of ceftazidime was determined in the aqueous humor and the vitreous body of normal, vitrectomized and aphakic/vitrectomized eyes and in the serum of albino rabbits 1 h after intravenous injection...

...Masatsugu Nakamura; Eiichi Shirasawa; Mitsushi Hikida We characterized the interaction of the prodrug dipivefrin hydrochloride (DPE) with esterase activity in the rabbit cornea. The esterases which were identified included: (1) cholinesterase, (2) acetylcholinesterase, (3) a mixture containing car...

... pressure, the effects of two systemic antihypertensive drugs were determined in the conscious rabbit. Topical, unilateral administration of either hydralazine or prizidilol did not lower the intraocular pressure of either eye. A bolus intravenous injection of either hydralazine or prizidilol caused...

..., and an estimation of blood oxygenation are possible. Experimental studies with fluorescent dyes can also be performed using special filters. In albino rabbits, no apparent vascular disturbances were observed under certain experimental conditions. Touching a ciliary process with the tip of the endoscope immediately...

...Olli Oksala; Johan Stjernschantz; Kai von Dickhoff This study was undertaken to characterize the mechanism of ocular irritation to YAG laser capsulotomy in rabbits. The blocking agents were administered intravitreally. ( D -Arg 1 , D -Pro 2 , D -Trp 7,9 )-SP, a substance P antagonist, tended...

...Keiko Yamaguchi; Seiji Hayasaka; Satoshi Hara; Takashi Shiono; Katsuyoshi Mizuno We examined biochemically the distribution of lysosomal enzyme activities in the ocular tissues and adnexa of albino rabbits using p -nitrophenyl derivatives. The pink and white lobes of Harderian gland disclosed...

...A.A.L.M. Rondas; H.W.G.M. Boddeke; H.N. Doods; L. Thörig; N.J. van Haeringen; P.A. van Zwieten The cholinergic receptors in rabbit isolated rectus muscle preparations were characterized by means of cholinergic agonists and antagonists. The concentration-dependent contraction induced...

... processes. Electron microscopically, the basolateral labyrinth of the PE appeared enormously enlarged, forming wide protein-containing intercellular spaces. These findings suggest that the function of the iridial ciliary processes in rabbits has a dual nature. Under normal circumstances, the main function...

...Jose N. Fernandez del Cotero; Sergio Bonafonte; Aguirre Vila-Coro Central, full-thickness excisional wounds were made in rabbit corneas to evaluate the biomicroscopic changes during the scarring process. Within the first minutes, the wound is closed with a fibrin clot. A timely microscopic study...

...Jarvis T. Chan; Lisa Cheeks; Tracey Slagle; Keith Green Tear fluoride concentrations were determined in rabbits and man. Tear fluoride levels in reflex tears were higher in rabbits (2–10 µmol/l) than in man (1.4–4 µmol/l), while plasma levels were quite similar in both species (1.5–4 µmol/l...