...Manhong Xu; Xiaoe Fan; Xinyuan Huang; Xin Chen; Yan Shao; Xiaorong Li Introduction: The efficacy and influence of steroids for reducing the incidence of proliferative vitreoretinopathy (PVR) after rhegmatogenous retinal detachment (RRD) surgery remain controversial. Systematic review and meta...

...Olga Reitblat; Edward Barayev; Orly Gal-Or; Maria Tsessler; Assaf Dotan Introduction: The purpose of this study was to evaluate the effect of intravitreal injection of tissue plasminogen activator (tPA) on proliferative vitreoretinopathy (PVR). Methods: PVR was induced in a rabbit model...

... retinal detachment (RRD) and the development of proliferative vitreoretinopathy (PVR). The purpose of this review is to provide an update on the signaling molecules in the vitreous and subretinal fluid (SRF) involved in these processes. A detailed literature search was performed in PubMed database until...

... of proliferative vitreoretinopathy (PVR), the current review sorted and analyzed representative animal models for pharmacotherapy of PVR since 1976. Proliferative vitreoretinopathy Animal model Pharmacotherapy Drug The earliest developed models of PVR often injected dermal fibroblasts to initiate PVR...

...Jun Zhang; Nalei Zhou; Bin Zhang; Jingxue Ma Background: This study aimed to explore the inhibitory effect of biodegradable scleral plugs containing curcumin on rabbits with proliferative vitreoretinopathy (PVR). Materials and Methods: The biodegradable scleral plugs containing curcumin were...

...Ferenc Kuhn; Susana Teixeira; David E. Pelayes Introduction: Certain injuries, especially those with a deep-impact (involving the choroid and even the sclera) intraocular foreign body (IOFB), have a high risk for developing either full-blown proliferative vitreoretinopathy (PVR) or full-thickness...

...Mehmet Citirik; Emrah Utku Kabatas; Cosar Batman; Kadir Okhan Akin; Naciye Kabatas Purpose: To assess vitreous vascular endothelial growth factor (VEGF) concentrations in proliferative diabetic retinopathy (PDR) in comparison to proliferative vitreoretinopathy (PVR). Patients and Methods: Vitreous...

...Miao-li Lin; Yong-ping Li; Zhan-rong Li; Jian-xian Lin; Xiao-lai Zhou; Dan Liang Purpose: Our aim was to establish a rat model of proliferative vitreoretinopathy (PVR) induced by macrophages and investigate whether macrophages can be a cell origin of fibroblast-like cells present in PVR. Methods...

...H.L.J. Knorr; M. Linde-Behringer; B. Gossler; U.M. Mayer Retinal pigment epithelium (RPE) cells migrating through the damaged retina into the vitreous body seem to play an important role for the pathogenesis of proliferative vitreoretinopathy (PVR) and other proliferative retina diseases. It is so...

...Daniel Mojon; Daniel Boscoboinik; Anita Haas; Matthias Bohnke; Angelo Azzi Retinal pigment epithelium (RPE) cells migrating through the damaged retina play an important role in the pathogenesis of proliferative vitreoretinopathy (PVR). We found that α-tocopherol (vitamin E) inhibits proliferation...

... diseases, including retinitis pigmentosa, tumors such as retinoblastoma or melanoma, and acquired proliferative and neovascular retinal disorders. We have demonstrated the feasibility of ocular gene therapy in a rabbit model of proliferative vitreoretinopathy, using retroviral vectors containing the herpes...

...Christophe Baudouin; Danièle Fredj-Reygrobellet; Françoise Brignole; Florence Nègre; Philippe Lapalus; Pierre Gastaud Mechanisms accounting for the development of proliferative vitreoretinopathy (PVR) in patients with rhegmatogenous retinal detachment remain poorly understood. In a previous study...

... a similar role in proliferative intraocular disorders (PID). Using immunochemistry, however, we could not label lactoferrin in surgically obtained membrane specimens from patients with idiopathic proliferative vitreoretinopathy (PVR), traumatic PVR, and proliferative diabetic retinopathy (n = 15...

... chemotaxis by 93%). Migration of RPE cells has been implicated in the pathogenesis of proliferative vitreoretinopathy (PVR). Inhibition of protein carboxymethylation may provide a new target in the development of pharmacologic therapy for PVR. 9 06 1987 21 08 1987 9 12 2009 © 1988 S...

...Zhao-Yang Wang; Li-Jun Shen; Ke-Ke Zhao; Zong-Ming Song; Jia Qu Aim: Our purpose was to determine the vitreous erythropoietin (EPO) level in patients with rhegmatogenous retinal detachment (RRD) and proliferative vitreoretinopathy (PVR). Methods: The levels of EPO in vitreous were measured using...

... or proliferative vitreoretinopathy (PVR). It is not known whether such an imbalance is already present in early PVR stages. We therefore analyzed VEGF and PEDF concentrations in subretinal fluids prior to PVR development. Methods: A large number (n = 137) of subretinal fluid samples were obtained at the time...

...J. Carlos Pastor; M. Carmen Méndez; Miguel A. De la Fuente; Rosa M. Coco; José García-Arumí; Enrique Rodríguez de la Rúa; Nieves Fernández; M. Antonia Saornil; Manuel J. Gayoso To report the major intraretinal pathological changes in retinas with proliferative vitreoretinopathy (PVR) and retinal...

...Maria Sydorova; Mun Seng Lee Purposes: To confirm the role of vascular endothelial growth factor (VEGF) in the pathogenesis of proliferative diabetic retinopathy (PDR) and proliferative vitreoretinopathy (PVR) and to investigate the relationship between the level of VEGF in serum and its vitreal...

...QianYing Gao; Jian Ge Purpose: Hypericin, a specific inhibitor of protein kinase C, has been reported to have potential as a therapeutic drug for proliferative vitreoretinopathy (PVR) in vitro and in vivo. In the present studies, we analyzed the dynamic changes in Ca 2+ influx and free...

.... Lang University Eye Hospital and Clinic of Ulm, Ulm, Germany Key Words Growth factors W Retinal pigment epithelial cell migration and proliferation W Proliferative vitreoretinopathy Abstract Background: To examine the effects of platelet-derived growth factor (PDGF), basic fibroblast growth factor...