...Hong Liang; Françoise Brignole-Baudouin; Luisa Riancho; Christophe Baudouin The study used a validated acute in vivo model to compare a new formulation of travoprost 0.004% ophthalmic solution (travoprost PQ), preserved with polyquaternium-1 (PQ), with commercially available formulations...

... to a benzalkonium-chloride-containing antiglaucoma drug. Methods: Timolol preserved with 0.01% benzalkonium chloride solution was applied b.i.d. in 1 eye of 10 rabbits for 56 days. Unpreserved timolol solution was used as control. Ocular surface changes were assessed weekly combining clinical examinations, in vivo...

...Pierre-Jean Pisella; Kathleen Fillacier; Pierre-Paul Elena; Caroline Debbasch; Christophe Baudouin Thirty-six albino rabbits, randomly divided into six groups, were used to study their ocular tolerance to (a) 0.25 and 0.50% Timoptol ® preserved with 0.01% benzalkonium chloride, (b) 0.25 and 0.50...