...Alexa Klettner; Friederike Möhle; Ralph Lucius; Johann Roider The retinal pigment epithelium (RPE) is the most active phagocyte in the human body, and this function is indispensable for vision. In this study, we introduce an easy and inexpensive way to quantify RPE phagocytosis by opsonizing FITC...

...Cheryl Y. Gregory; Carolyn A. Converse; Wallace S. Foulds A sensitive radioimmunoassay has been developed which allows rapid quantitation of rod outer segment (ROS) phagocytosis by retinal pigment epithelial (RPE) explants in vitro. It involves the use of an antiopsin antiserum, in conjunction...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Macrophages Vitreous Retina Phagocytosis Latex particles Original Papers Ophthalmic Res. 14:317-325 (1982...

...Nobuchika Ogino; Miyo Matsumura; Hiroyasu Shirakawa; Isamu Tsukahara Cultured chick retinal pigment epithelial cells phagocytosed polystyrene latex particles. The phagocytosis was inhibited very specifically by melatonin, which attained 50% inhibition at about 10 ––16 M . Other indole compounds...

...Miyo Matsumura; Ryoji Yamakawa; Hiroyasu Shirakawa; Nobuchika Ogino Phenothiazines (chlorpromazine, trifluoperazine, prochlorperazine, and fluphenazine) showed dose-dependent inhibition of phagocytosis of latex particles by cultured chick retinal pigment epithelial cells at concentrations of 10 -5...

... phases of target cell desctruction in the retina. Initially there was a coagulative necrosis of the outer segments of the photoreceptor cells, followed by phagocytosis of these outer segments by mononuclear cells. Next, there was hydropic degeneration and necrosis of the inner segments and the cell...

...Miyo Matsumura; Nobuchika Ogino; Hiroyasu Shirakawa; Ryoji Yamakawa; Isamu Tsukahara We observed cultured retinal pigment epithelial cells as they responded to the introduction of latex particles. The cells showed phagocytosis of particles 1 h after administration of latex and were filled...

...Emeline F. Nandrot; Silvia C. Finnemann Background/Aims: Diurnal phagocytosis of spent photoreceptor outer segment fragments by the retinal pigment epithelium (RPE) is critical for vision. We recently identified an important role for αvβ5 integrin receptors and their ligand Milk fat globule-EGF...

.... However, CpG-DNA motif enhanced phagocytosis in RPE cells. These results may indicate that TLR 3 and 9 play a distinct role in the inflammatory response that clears viruses from the retina. 23 05 2006 2 02 2007 25 5 2007 © 2007 S. Karger AG, Basel 2007 Copyright / Drug Dosage...

... of cytoskeleton (microtubuli, actin) and osmotic swelling were also tested. Ingested FITC-labeled microparticles were found in phagosomes strongly associated which the cytoskeleton as they could not be easily moved by laser tweezer microscopy. Phagocytosis was observed predominately during dark intervals...

..., but, comparable to MonoMac6, IFN-γ induced neopterin in the human RPE. Interestingly a diurnal rhythm of phagocytosis was observed which was influenced by light exposure suggesting that RPE cells maintain their circadian rhythm also in cell culture to a certain extent. This study further demonstrates...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Gene expression Macrophage Mannose receptor Phagocytosis Retinal pigment epithelium Original Paper Ophthalmic Res...

...Jun-ichi Kogishi; Masayuki Akimoto; Michiko Mandai; Shoji Kuriyama; Michael O. Hall; Yoshihito Honda; Nagahisa Yoshimura Purpose: To investigate a possible role of the nitric oxide (NO)-cGMP signal transduction system in phagocytosis of rod outer segments (ROS) by cultured retinal pigment...