... Neuroprotection Oxidative stress Mitochondrial dysfunction In another study on prediabetic animals, neurodegeneration preceded vascular changes. Prediabetic mice of this study had a lack of LDL receptors and overexpression of insulin-like growth factor 2. Changes in three layers, including the inner...

..., pathogenesis, genetics, epigenetics, autophagy, oxidative stress, inflammation, mitochondria, matrix, and complement. Articles published in English and Spanish between 2015 and 2021 were included. We selected all experimental and clinical studies that fit our search. All articles underwent critical reading...

... stem cells-based cell therapy could contribute to the maintenance of the retinal homeostasis. We have explored the effect of human uterine cervical stem cells (hUCESCs)-conditioned medium (hUCESC-CM) on RPE cells under oxidative stress condition. Methods: ARPE-19 cells were treated with hydrogen...

...Kholoud Bokhary; Feda Aljaser; Manal Abudawood; Hajera Tabassum; Afnan Bakhsh; Shatha Alhammad; Rawan Aleyadhi; Faisal Almajed; Roua Alsubki Background: Diabetic retinopathy (DR) is a sight-threatening complication of diabetes mellitus (DM). Oxidative stress generated on account of hyperglycemic...

...Yuanyuan Zou; Bingjie Cui; Pei Liang; Xiaoyu Tian; Yiming Ma; Shaozhen Zhao Backgrounds/Aims: To explore whether NLRP3 is involved in the development of cataract and to study the effect of NLRP3 on hydrogen peroxide (H 2 O 2 )-induced injury in human lens epithelial cells. Methods: Oxidative stress...

... formation, inflammation, and oxidative stress-associated molecules were examined. Our results demonstrated that FA, but not MET, played a protective role against retinal thinning in the early stage of DR in db/db mice, although FA did not exhibit antihyperglycemic effect. In addition, retinal expression...

... effects in the retina, particularly against inflammation and oxidative stress. Therefore, in this work CaD was administered, for 2 weeks, to diabetic animals, after 6 weeks of diabetes (2 months of total duration of diabetes), when proinflammatory events are already implemented in the retina, in order...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. miRNA Glaucoma Aqueous humor Trabecular meshwork Extracellular matrix Oxidative stress Small RNAs (microRNAs or miRNAs), which are 21...

...Li Chen; Yun Qi; Xinguang Yang Aims: Crocin, a pharmacologically active component of Crocus sativus L. (saffron), has been reported to be useful in the treatment of oxidative stress injury. In the present study, we investigated the antioxidative effect of crocin and the change of the ERK signaling...

...-related macular degeneration. This study investigated the expression of 2 best-characterized endoplasmic reticulum (ER) stress markers, glucose-related protein 78 (GRP78) and C/EBP homologous protein (CHOP), as well as their regulation by oxidative stress after blue light-mediated damage of A2E-containing...

... (ARPE-19) exposed to oxidative stress. Methods: ARPE-19 cells unexposed or exposed to oxidative stress (hypoxic chamber) were treated for 1 min with one of the dyes. RPE proliferation was measured by 3 H-thymidine incorporation, adhesion by ability to adhere to fibronectin, and safety by annexin V...

...Lina Huang; Shihong Zhao; John H. Zhang; Xuejun Sun Objective: Retinal neovascularization or retinopathy is a proliferative disorder of the retinal capillaries and is the primary cause of blindness. Some studies have shown that oxidative stress plays an important role in hyperoxia-induced retinal...

... was monitored weekly using a slit lamp and lens gray value analysis. Concentrations of reactive oxygen species (ROS), reduced glutathione (GSH) and malondialdehyde (MDA) in rat lenses were measured to determine the role of oxidative stress in cataract induction. Results: By week 4, the cortical gray value...

...C. Cagini; A. Giordanelli; T. Fiore; R. Giardinieri; B. Malici; G.E. De Medio; M.A. Pelli; F. De Bellis; E. Capodicasa Purpose: A variety of factors have been implicated in the pathogenesis of age-related macular degeneration (ARMD), and oxidative stress plays an important role in the onset...

...Hong Wang; Zhi Zheng; Yuanyuan Gong; Bijun Zhu; Xun Xu Oxidative stress plays a role in the pathogenesis of neurodegeneration in diabetic retinopathy (DR). However, whether an excellent reactive oxygen species scavenger, U83836E, inhibits the neurodegeneration in DR remains uncertain. This study...

... micronutrients and antioxidants as well as oxidative stress with cataract. Dietary interventions as strategy for prevention of cataract and other ocular disorders are also reviewed. Conclusions: Consumption of food-based antioxidants like β-carotene lutein and zeaxanthin seem to be useful for the treatment...

... compared to control subjects. Conclusion: TAC decreases while the oxidative stress increases in PEX. 28 12 2007 19 05 2008 31 12 2009 © 2009 S. Karger AG, Basel 2009 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Lens Phenazine methosulfate Oxidative stress Electron spin resonance Hydroxyl radical Superoxide anion Experimental...

... an anti cataract effect of ascorbate. Pyruvate is another agent useful in this regard. Ascorbate Lens Vitamin C Oxidative stress Oxygen radicals Cataracts 10 12 2009 © 1988 S. Karger AG, Basel 1988 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Proton nuclear magnetic resonance Hexose monophosphate shunt Lactate Light adaptation Retina Oxidative stress Ophthalmic Res. 19: 298-302...