... inadequately controlled on maximum tolerated medical therapy with intraocular pressure (IOP) ≥18 and ≤40 mm Hg. The MicroShunt was implanted ab externo with adjunctive use of mitomycin C (0.2–0.4 mg/mL applied for 2–3 min), alone or in combination with cataract surgery. The primary effectiveness endpoints were...

...Chiara Del Noce; Aldo Vagge; Carlo Enrico Traverso Purpose: To evaluate the effects and complications related to use of mitomycin C (MMC) as an adjunctive therapy in bleb needling. Methods: Retrospective review of the records of patients affected by open-angle glaucoma who underwent a bleb revision...

... were included in the meta-analysis. The primary outcome was postoperative mean IOP at the 12-month follow-up. No significant difference in IOP was found between the bevacizumab + antimetabolite (mitomycin c or 5-fluorouracil) group and the antimetabolite alone group (weighted mean difference –0.27; 95...

...Fathi El-Sayyad; Heba Magdy Ahmed El-Saied; Mohamad Amr Salah Eddin Abdelhakim Background: We assessed bleb morphology and the intraocular pressure (IOP)-lowering effect of trabeculectomy with ologen compared to mitomycin C (MMC) in juvenile open-angle glaucoma (JOAG). Methods...

...Teiichiro Murayama; Nobuo Takahashi; Naohide Ikoma In order to evaluate the cytotoxicity of mitomycin C (MMC), the effects of MMC on cell viability, cell cycle and cell surface structure were studied using Chang’s cultured human conjunctival cells. A 4- or 2-min exposure to MMC at concentrations...

...Mahmoud Mohamed Ismail; Jorge L. Alió; José Mª Ruiz Moreno To prevent the development of secondary cataract, mitomycin C (MC, 0.2 mg/ml) and 5-fluorouracil (5-FU, 50 mg/ml) were introduced in the irrigating solution (BSS Plus) during an extracapsular lens extraction in albino rabbits. Cellular...

...Hyun-Kyung Park; Kwang-Won Lee; Jun-Sub Choi; Choun-Ki Joo The mode of action of mitomycin C (MMC)-induced cell death in lens epithelia was investigated using cell culture system. The cytotoxicity of MMC on α-TN4 mouse lens epithelial cells (LECs) was measured by using 3-(4,5-dimethylthiazol-2-yl...

...Jong Soo Lee; Boo Sup Oum; Sang Hyup Lee The purpose was to investigate the biological effects of mitomycin C (MMC) on the inhibition of cellular proliferation and the subsequent synthesis of extracellular matrix like type I collagen (PIP) and laminin on primary and recurrent pterygia. The 3 H...

...Nobuo Takahashi; Teiichirou Murayama; Madoka Oda; Minoru Miyakoshi The present study was performed to clarify the effects of a 4-min exposure of mitomycin C (MMC) on cell growth, the cell cycle and MMC dose incorporated into DNA, using Chang’s cultured human conjunctival cells. A low dose of MMC...