...Brooks H. Rohde; Ming Zhu; Salwa El Messiry; George C.Y. Chiou Levels of melatonin in rabbit eye tissues were detected by radioimmunoassay. Solutions of met-enkephalin, leu-enkephalin, α-endorphin and β-endorphin were given topically. Met-Enkephalin and α-endorphin lowered levels of melatonin...

...Brooks H. Rohde; Byron H.P. Li; George C.Y Chiou Melatonin injected into the vortex vein of a rabbit eye produced an increase in intraocular pressure (IOP) which lasted for up to 5 h. Injection of haloperidol caused a decrease in IOP; this effect was totally reversed by melatonin. It is probable...

...George C.Y. Chiou; Marsha A. McLaughlin It has been reported that diurnal changes in intraocular pressure (IOP) may be related to the fluctuation of melatonin levels in the eye. In order to test this hypothesis, effects of methysergide, tranylcypromine, and p -chlorophenylalanine (PCPA) on IOP...

...) than at 09:00 hr (2.18 ± 0.16 nmoles/mg protein/hr) indicating that melatonin might be involved in the diurnal changes in IOP. Intracameral injections of various agents into rabbit eyes revealed that melatonin but not serotonin nor N-acetylserotonin raised IOP markedly, indicating that melatonin...

...Hiroyasu Shirakawa; Nobuchika Ogino Melatonin (100 n M– 100 μ M ) showed a chemotactic action on cultured chick retinal pigment epithelial cells. This effect was equivalent to that of N-formyl methionyl-leucyl-phenylalanine. Other methoxyindole derivatives had no or less chemotactic effects than...

...Nobuchika Ogino; Miyo Matsumura; Hiroyasu Shirakawa; Isamu Tsukahara Cultured chick retinal pigment epithelial cells phagocytosed polystyrene latex particles. The phagocytosis was inhibited very specifically by melatonin, which attained 50% inhibition at about 10 ––16 M . Other indole compounds...