... was observed in aged a-crystallin isolated from senile human lenses [ 17, 25], It has been suggested that a-crystallin along with the chaperone GroEL has the ability to protect glucose-6-phosphate dehydrogenase against glycation [24], However, our data demonstrated that a-crystallin is itself readily glycated...

..., Milton RC, Srivastave S. Ansari N, the Lens Opacities Case-Control Study Group: Biochemical factors in the lens opacities case-control study. Arch Ophthalmol 1995:113:11 131119. 5 Shui YB, Kojima M, Hockwin O, Sasaki K: In vivo morphological changes in rat lenses induced by the administration...

... during this breakdown of the stores arc accommodated by other cytoplasmic stores. In a recent cytochemical study by Vrensen et al. [5] it was shown that in rat lenses the limiting mem­ branes of lens fibers arc able to bind consider­ able amounts of calcium. The present cytochemical investigation aimed...

...:421 424. 6 Hendrickson Ph. Robert Y: Con­ trast transfer ratio in normal, cataractous. and intraocular implant lenses: A clinical photopapillometric study. Graefes Arch Clin Exp Oph­ thalmol 1986;224:191-194. 7 Robert Y, Hendrickson Ph: Pho­ tometry of the optic disc; in Lambrou GN. Greve EL (eds...

.... However, mRNA levels for calpain I in whole lens appeared to be lower compared to calpain-II mRNA. Participation of calpain I in crystallin precipitation during normal maturation of rodent lenses or cataract formation is thus theoretically possible, but unlikely, because of the low level of expression...

... was found in the nucleus, followed by the deeper anterior and deeper posterior cortices, the shallow anterior and shallow posterior cortices, and the equatorial region. The topographic α-Toc. distribution in the lens did not differ between lenses of 1-, 4- and 12-month-old rats. A significant decrease of α...

...John L. Hess; Kenneth P. Mitton; G.E. Bunce Selenite treatment of the preweanling rat stabilized the transparency of the lens nucleus to decreasing temperature. Hence, we compared properties of the cortex and nucleus from lenses of selenite-treated and age-matched control rats. A subcutaneous dose...

... the discovery of glutathione in the lens hy Arnold [1] in 19101911. Evidence for glutathione biosynthesis had been achieved in cultured lenses as well as syn­ thesis of an analogue, ophthalmic acid, in lens homogenates [2, 3], However, stepwise synthe­ sis of glutathione and pathways for its catabo­ lism...

...H. Rink; A.A. El-Layeh; J. Bours; M.H. Emarah Cataractous lenses from an extended population of 100 Egyptian patients whose age, sex and case history had been recorded, were collected and classified morphologically. After determination of the lens wet weights, lenses were microsectioned and basic...

... of cataractous lenses were compared with each other, with those of sclerotic lenses and with a normal lens profile. The alterations in the composition of high-molecular-weight (HMW)-, α-, β H -, β L -, β S -, and γ-crystallins along with normal aging, are superimposed by pronounced cataract-related changes which...

... mittels Lincar-Dcnsitomctrie von Scheimpflug-Photographicn. Fortschr Ophthalmol 1985:82:374 376. 7 Olbert D, Baumgärtner A. Hockwin O, Wahl P, Hasslacher Ch: Follow-up o f lenses o f diabetics by means of linear densitometry of Scheimpflug photos. Lens Res 1986;3:217-225. 8 Olbert D, Ilockwin O...

... related to age. Curr Eye Res 1983:2:735 742. 34 Rogers KM. Augustyn RC: Glutathi­ one reductase in normal and cataractous human lenses. Exp Eye Res 1978:27:719-721. 35 Reddan JR, Giblin FJ, Dziedzie AC, McCready JP, Reddy VN: Influence o f age on the ability of lens epithelia to detoxify H;0 ;. J Cell...

... Lens Fiber Membranes Fig. 3. A Dark-field image o f an extracted donor lens exhibiting the small peripheral opac­ ities common in lenses of donors over the age o f 40. The framed area of A shows in SEM that these opacities are parts o f a group o f fibers surrounded by abnormal globular membranes seg­...

...Masami Kojima; Ying Bo Shui; Kazuyuki Sasaki Topographic distribution of prednisolone in the lens after organ culture was investigated. Freshly enucleated pig lenses were divided into two groups; the complete vitreous was removed from the lenses in group A, and the adherent parts of the vitreous...

... of Biochemistry of Macromolecules, and c Research Center on Computational Sciences, 2nd University of Naples, Italy Key Words Cataractogenesis Phospholipids Fatty acids Membrane Lens Fatty Acid Composition of Membrane Phospholipids of Cataractous Human Lenses Abstract The effect of lipid peroxidation on fatty...

...Paul S. Wallace; Susan V. Duff; Alan R. Prescott; Dennis Goebel; Harry Maisel; Roy A. Quinlan The lens-specific intermediate filament (IF) proteins CP49 and filensin have been identified in a large number of evolutionary divergent species. In the chick lens both CP49 and filensin have been...

... to the amino groups of the lens proteins, is supposed to be one of the causes for cataract develop­ ment through the Maillard reaction [1]. Ly­ sine seems to be the most probable target ami­ no acid for this reaction [2]. In vivo and in vitro studies on cataractous lenses from animals and humans led...

...E.J.A. Lea Age-related lens opacity is the major cause of loss of vision affecting more than half of the world’s blind. The development of cataract is associated with changes in the structure of the lens. The lens consists largely of closely packed fibre cells forming a transparent syncytium...

...-ATPase and the Ca-channel. In lenses from different species calpains have been detected in decreasing amounts from the epithelium to the cortex to the nucleus. Several substrates for calpain in the lens have been demonstrated: crystallins, vimentin, actin, beaded filaments and MP26 among others. Both...

...Julia M. Marcantonio Ionic homeostasis is essential to lens clarity and the lens epithelium plays a large part in homeostasis, through vectorial transport. In most epithelia maintenance of vectorial function depends on the cytoskeleton. Capsule/epithelium preparations from human donor lenses have...