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Keywords: Insulin
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Journal Articles
Subject Area:
Ophthalmology
Ophthalmic Res (1989) 21 (4): 292–296.
Published Online: 10 December 2009
... with an aldose reductase inhibitor or insulin completely normalized the tonicity. Seven days after feeding, the galactose-fed animals already showed lens opacities, while diabetic rat lenses remained clear even after 21 days after diabetes induction. These results indicate insignificant osmotic changes...
Journal Articles
Subject Area:
Ophthalmology
Ophthalmic Res (1989) 21 (3): 167–174.
Published Online: 10 December 2009
...J.C. Bizec; J. Klethi; P. Mandel Adenylate cyclase activity of bovine lens epithelial cells is activated by guanine nucleotides or fluoride. Additional activation to that of guanylylimidodiphosphate [Gpp(NH)p] was induced by isoproterenol. Insulin was found to inhibit adenylate cyclase activity...
Journal Articles
Subject Area:
Ophthalmology
Ophthalmic Res (1972) 3 (2): 65–82.
Published Online: 09 December 2009
...J.R. Reddan; C.V. Harding; H. Rothstein; M.W. Crotty; P. Lee; N. Freeman Rabbit and frog lens epithelial cells can be induced to undergo DNA synthesis and mitosis in a completely defined insulin containing medium. The hormone was added to Medium 199 in these experiments. In general, the insulin...
Journal Articles
Subject Area:
Ophthalmology
Ophthalmic Res (1983) 15 (1): 29–37.
Published Online: 04 December 2009
...Edward Cotlier; Charles Davidson A system for isolation of capillaries from the retina has been adapted to biochemical studies in vitro. Insulin receptors were identified in human and calf retinal blood vessels. Binding of 125 I insulin by calf retinal blood vessels takes place through high...
Journal Articles
Subject Area:
Ophthalmology
Ophthalmic Res (1982) 14 (2): 148–152.
Published Online: 04 December 2009
...Mihir Bagchi Freshly isolated lenses incubated in either M-199 alone or supplemented with serum or insulin were measured for α- and γ-crystallin synthesis. It was found that synthesis of these crystallins were not altered by addition of either serum or insulin in the culture medium. The α...
Journal Articles
Subject Area:
Ophthalmology
Ophthalmic Res (1981) 13 (2): 65–71.
Published Online: 04 December 2009
... is abnormal in this disorder. Additionally, it was found that insulin significantly decreased the rates of oxygen consumption and glucose uptake by normal corneas and the corneal epithelium appears to be selectively effected by the hormone. Cornea Diabetes Glucose uptake Insulin Oxygen consumption...
Journal Articles
Subject Area:
Ophthalmology
Ophthalmic Res (1986) 18 (6): 357–362.
Published Online: 04 December 2009
...John B. Coulter,III; David K. Eaton; Linda K. Marr Since increased lens sorbitol and osmotic swelling are central causative features of cataract in diabetic rats, the effects of insulin treatment on lens sorbitol, water, sodium, and potassium were studied. The sorbitol concentration in early stage...
Journal Articles
Subject Area:
Ophthalmology
Ophthalmic Res (1977) 9 (5): 269–275.
Published Online: 03 December 2009
...John B. Coulter, III; Robin L. Knebel In order to evaluate more clearly the possible physiological effects of insulin on the lens, insulin was measured in the aqueous humor and plasma of rabbits in the fasting state and at hourly intervals after refeeding. The mean insulin concentration in plasma...
Journal Articles
Subject Area:
Ophthalmology
Ophthalmic Res (1970) 1 (2): 72–78.
Published Online: 27 November 2009
...T.G. Farkas; Y.L. Mahajan In the presence of Glucose Tolerance Factor, an organometallic complex, in vitro insulin exerted a stimulatory effect on glucose utilization of isolated, intact lenses. In high concentrations both the hormone and the Glucose Tolerance Factor were inhibitory. This paper...