...-nm laser was employed to induce CNV in guinea pig. The development of neovascularization was measured comprehensively by fundus fluorescein angiography, optical coherence tomography and hematoxylin and eosin staining. Gene expression was detected by real-time polymerase chain reaction...

...Bo Ou; Shinichi Ohno; Nobuo Terada; Yasuhisa Fujii; Hai-Bo Chen; Shigeki Yamabayashi; Shigeo Tsukahara The ultrastructure of the cytoskeleton of optic nerve axons in guinea pigs was examined by the quick-freezing and deep-etching (QF-DE) method. The optic nerve tissues were treated with 0.5...

...Andrea Leonardi; Kurt J. Bloch; Rebecca Briggs; Mathea R. Allansmith The ocular late-phase reaction (LPR) is a mast cell-dependent, delayed inflammatory reaction developing 4–12 h after the early-phase reaction (EPR). We developed a passive IgGl antibody-dependent guinea pig model that clinically...

...M. Saari; G. Johansson; A. Huhtala The organization of the myel inated nerves of the guinea pig iris was visualized by trypsin digestion and bleaching technique with PAS-haematoxylin or Sudan black staining. These nerves form a well-developed network which is especially dense in the papillary part...

...J.J. Donnelly; J.H. Rockey; A.E. Bianco; E.J.L. Soulsby Infection of inbred Strain 2 guinea pigs by subcutaneous or intradermal injection of fresh or cryopreserved living Onchocerca lienalis microfilariae, followed by a challenge intracorneal infection of microfilariae, resulted in serum...

...Hannu Uusitalo; Juha I. Lehtosalo; Arto Palkama The presence of vasoactive intestinal polypeptide(VIP)-like immunoreactivity, especially in the anterior part of the guinea pig uvea, was studied using an indirect immunofluorescence technique. In the ciliary body, thin varicose VIP fibers displaying...

...D. Friedburg; H. Kröner; L. Rosenstiel The influence of intravitreal injection of corticosteroids in guinea pigs on lens cation concentration, lens density and leucine-l-[ 14 C] incorporation into the lens protein was examined. 6-methylprednisolone acetate (Urbason-Kristallsuspension) led...

...A. Huhtala; G. Johansson; M. Saari Myelinated nerves of the iris of 12 guinea pigs were studied light-microscopically after stereotactic denervation of the ophthalmic division of the trigeminal nerve. The trypsin digestion and bleaching technique for demonstration of myelinated nerves of the iris...

...Mathea R. Allansmith; Robert S. Baird In an experiment designed to test one parameter of the antigenic potential of the hydrogel soft contact lens material polymacon (delayed hypersensitivity as shown by skin test), we divided 20 guinea pigs into four groups of 5. 5 guinea pigs were immunized...

...E.J.L. Soulsby; B.E. Stromberg, Jr.; John J. Donnelly; John H. Rockey Intravitreal injection of Toxocara canis and Ascaris suum larvae into guinea pigs is being studied as a model for human ocular toxocariasis. IgE antibody-mediated mechanisms may be of importance in the ocular immunopathologic...

...Kaili Wu; Masami Kojima; Ying Bo Shui; Hiroshi Sasaki; Kazuyuki Sasaki To evaluate ocular morphological response to ultraviolet B (UV-B) exposure in guinea pigs fed with normal and low-ascorbic acid (ASA) diets, 24 guinea pigs were randomly divided into UVR (normal diet + UV-B), LVC (low-ASA diet...