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Journal: Ophthalmic Research
Ophthalmic Res (1994) 26 (2): 124–128.
Published Online: 11 December 2009
... purpose was to study the histopathological changes in the eyelids caused by long-term systemic treatment of female New Zealand rabbits with isotretinoin (2 mg/kg) and etretinate (2 mg/kg). The histopathological evaluation showed degenerative changes in the meibomian gland acini, leading to cell necrosis...