...William C. Stewart; Lindsay A. Nelson; Bonnie Kruft; Jeanette A. Stewart Purpose: To identify current challenges facing ophthalmic pharmaceutical start-ups in developing new products. Methods: Surveys were distributed to the chief executive officer (CEO) or president of ophthalmic start-ups...

... University School of Medicine, Tsu, and d Department of Biochemistry, Institute for Developmental Research, Kasugai, Japan Key Words Heat shock protein 28 Lens Development Human embryo Immunohistochemistry Immunohistochemical Study of 28-kD Heat Shock Protein in the Lens of Young Human Embryos Abstract...

... identified by monoclonal antibodies during the development of chick embryos provide us with information on the putative func­ tions of these antigens. Frozen sections of chick embryo eyes at various developmental stages were used. Before 66 h of develop­ ment (stage 18-19), none of the antibodies reacted...

...L. Hazlett; Deanna Dudzik; Bill Harries Ocular mucin (mucus) development in the mouse was examined using several different fixatives and scanning electron microscopy. One of the fixatives, a picric acid –paraformaldehyde-glutaraldehyde (PA-P-G) preparation which fixes mucin at the adult mouse...

...J. Bours; H.J. Födisch Eight selected fetal lenses of 119–231 days of gestation were analyzed by capillary isotachophoresis. A reproducible separation into pre-α-, α-, β- and γ-crystallins was achieved. During development, an increase was observed in β s - and γ-crystallins, balanced by a decrease...

... or fraction. Within the lens, the changes of these parameters are gradual and continuous. The lens nucleus contains the highest amounts of DW and WI fraction, and the lowest amounts of water and WS crystallins. There is a relative dehydration of the lens during development and ageing, most pronounced...

... in Celestial Goldfish Developmental Study M. Matsumura, M. Ohkuma, Y. Honda Department of Ophthalmology (Director: Prof. I. Tsukahara), Faculty of Medicine, Kyoto University, Kyoto, Japan Keywords. Retinal degeneration Goldfish Development Pigment epithelium Photoreceptor Outer segment Phagocytes...

...Annemarie Hohmann; Wolfgang Haase An acuity test was developed with defined space between symbols to determine the effect of crowding on visual line acuity. The test differentiates between normal sighted subjects, those with low but uncorrected refractive errors and amblyopes. Furthermore, the test...

...R. Praus; I. Brettschneider Human corneas were analyzed for glycosaminoglycans during various stages of embryonic development and at different postnatal ages. The development and aging of the cornea was accompanied by a transient increase of glycosaminoglycan hexosamine up to 2 years of age...

..., instructions or products referred to in the content or advertisements. Tapetum lucidum Beagle Hereditary Fluorescein angiography Development Fundus Retinal vessels Melanin Ophthalmic Res. 7: 250-260 (1975) Hereditary Tapetal Abnormality in the Beagle' Roy W. Bullhorn, M argaret B. Bellhorn...

...R. Praus; I. Brettschneider The development and aging of the chicken cornea is accompanied by the stepwise disappearance of the non-sulphated glucosaminoglycan and by the increase of keratan sulphate and chondroitin sulphate content. After hatching, keratan sulphate becomes a predominant part...

... the mature retina and layering. Similar to the high activity period in brain development known as the brain growth spurt [9], the visual system presents a critical developmental stage, which extends from the last embryonal period to the end of the 1st postnatal (P) week [10]. In this period, crucial events...

... established that cone photoreceptor cells develop and appear earlier than rod photoreceptor cells in vertebrate retinas [13]. Since this development is mainly observed after birth in rats, a developmental study of MLGAPC involving postnatal rats will answer the question of whether the above speculation...

... development. In an attempt to elucidate the precise role of TH in the developing eyes and adnexa (orbit, lids, nasolacrimal structures), we analysed the craniofacial and eyeball developmental characteristics in a rat model of congenital-neonatal hypothyroidism (HG), induced by combined chemical-surgical...

... that this developmental role of GABA is mediated through GABA A receptors. Retinal cell transplants are being tried for the treatment of degenerative retinal disorders. Even though the donor tissue continues to proliferate, to develop and to differentiate after transplantation, its development is not entirely normal...

... of Medicine, Tsu, Mie, Japan; c Department of Biochemistry, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO Key Words Go Eye opening Dark adaptation Retina Rat Development Enzyme immunoassay Immunohistochemistry Does Light Stimulus...