... inhibitor, significantly lowered IOP at concentrations of more than 30 μ<sc>m</sc> in normotensive rabbits. Other Hsp90 inhibitors also significantly lowered IOP in normotensive rabbits at a dose of 100 μ<sc>m</sc>. No reduction of aqueous humor production was observed by injection...

... by upregulated heat shock protein 47 (HSP47) expression, can produce scarring in rat conjunctival blebs. Meanwhile, the presence of HSP47 in human aqueous humor and its levels are yet to be determined. Methods: We examined 32 consecutive patients with APAC and 16 age-matched participants without APAC scheduled...

...Beatriz Vidal-Villegas; Bárbara Burgos-Blasco; Jose Luis Santiago Alvarez; Laura Espino-Paisán; Jose Fernández-Vigo; Vanessa Andrés-Guerrero; Julián García-Feijoo; Jose María Martínez-de-la-Casa Introduction: Few studies have investigated glaucoma biomarkers in aqueous humor and tear and have found...

... was set as the endpoint of the treatment. Conclusion: In HIV-negative patients with CMVR, IL-8 was closely associated with CMV DNA concentration in the aqueous humor. The real-time aqueous level of IL-8 could be used as one of the evidences of disease recovery. [email protected] 4 09 2020 15...

...Ying Chen; Hong Yan; Guo Li; Yu Zhang Purpose: To assess the quantitative differences in the levels of members of the transforming growth factor (TGF-β), matrix metalloproteinase (MMP), and tissue inhibitor of MMP (TIMP) families in the aqueous humor (AH) between patients with acute primary angle...

...; the lectin pathway (LP), classical pathway (CP), and alternative pathway. To investigate the possible roles for the LP or CP in the development of neovascular age-related macular degeneration (nAMD), we compared aqueous humor levels of complement proteins of the LP and CP between eyes with nAMD and those...

... in the occurrence and development of glaucoma and widely participate in regulating biological processes of glaucoma-related genes. This article reviews the connection between the aqueous humor, trabecular meshwork, the apoptosis of retinal ganglion cells, and miRNA. The aqueous humor fills the anterior...

...) by comparing aqueous humor levels of 14 cytokines between eyes with polypoidal choroidal vasculopathy (PCV) and those with neovascular AMD. Methods: Forty eyes from 40 patients with treatment-naïve exudative AMD consisting of 18 eyes with neovascular AMD and 22 eyes with PCV were studied. Twenty eyes from 20...

... on the activation of the complement system in the aqueous humor in this disorder. Methods: Aqueous humor samples were collected during keratoplasty of 12 PBK patients, as well as during phacoemulsification surgery of 18 control patients. The concentrations of the protein-protein complexes generated during...

...Thomas Bertelmann; Nadia Kičová; Laura Kohlberger; Marta Spychalska; Stefan Strodthoff; Sebastian Irle; Stefan Mennel Purpose: To evaluate anterior segment anatomy and anesthetic and surgical techniques with respect to the amount of aqueous humor (AH) that can be sampled out of the anterior chamber...

... an uneventful cataract extraction. Aqueous humor (20 µl) was aspirated from the anterior chamber intraoperatively and processed for fibroblast growth factor (FGF) and epidermal growth factor (EGF) using an immunoassay method (ELISA). The lens material was subjected to histological examination. Results...

...Tae Wan Kim; Hum Chung; Hyeong Gon Yu Background: To compare the expression of chemokines in the aqueous humor and chemokine receptors in intraocular lymphocytes from Behçet and non-Behçet uveitis patients. Methods: A total of 95 uveitis patients were included in this study. We studied 39 Behçet...

... and human cataracts. In addition, aqueous humor from cataract patients was also analyzed. The level of GSSG in the nucleus of human cataracts was significantly higher than that in the nucleus of normal eye bank lenses. The capsule epithelium of intracapsular extracted cataracts possessed high levels...

... Department of Ophthalmology, Toyama Medical and Pharmaceutical University, Toyama, Japan Intracameral Ascorbic Acid, Glutathione and Protein Levels in Albino and Pigmented Rabbits Key Words Aqueous humor Ascorbic acid, reduced and total Glutathione, reduced and total Protein Abstract We performed...

... lens Aqueous humor Vitreous body Polycyclic aromatic hydrocarbons High-performance liquid chromatography Ophthalmic, Research Original Paper Ophthalmic Res 1997;29:172-176 Received: July 2, 1996 Accepted: December 5. 1996 PierEmico Gaiiengaa AnnaMorganteb Marco Ciancaglini* Luigia Pettib Ciro...

...Michael J. Doughty The aqueous humors of 100 freshly enucleated rabbit eyes were assessed within 10 min postmortem by taking samples in the last stage of corneal dissection following the Dikstein-Maurice procedure. Aqueous levels of partial pressure of carbon dioxide (pCO 2 ) averaged 58.2 ± 8.5 mm...

...Xiao-Bin Zheng; Qun Peng; Luo Sha Twenty-six samples of human aqueous humor from patients with cataract and glaucoma were analyzed on anticomplement activity. The mean inhibitory rate was 15.32 ± 14.60%, ranging from 0.93 to 60.02%. The inhibitory effect appeared in a dose-dependent manner...

... conditions. The hypothesis that aqueous humor polyamines could be used to follow the time course of an endotoxin-induced inflammation in the eye was investigated. Additional parameters studied were the amount of aqueous leukocytes, alkaline phosphatase activity, distribution of leukocyte subsets...

... and corneal endothelium, while not altering the oxidized fraction. BCNU increased the oxidized fraction of glutathione in the aqueous humor from 22 to 63% without significantly altering total glutathione levels. BSO, however, reduced total glutathione by 70% in the aqueous humor, and the oxidized fraction...

...C. Costagliola; G. Iuliano; M. Menzione; A. Nesti; F. Simonelli; E. Rinaldi In this study we have investigated the oxidative metabolism of red blood cells (RBC), plasma, serum, aqueous humor, and lens of healthy subjects and of age-matched cataractous patients with and without diabetes. Reduced...