...Shan Lin; Yuanzheng Peng; Mengtao Cao; Ruiting Chen; Jiying Hu; Zuhui Pu; Zhiming Cai; Lisha Mou Controversial results regarding the associations between aldose reductase (AR) genetic polymorphisms and diabetic retinopathy (DR) have been reported for many years. The present meta-analysis...

... buffer, A. elata extract was administered by daily oral tube feeding for 7 weeks. All mice were killed at 2 months after the last injection of STZ or saline and the extent of cell death together with the protein expression levels of TonEBP, aldose reductase (AR) and nuclear factor-kappa B (NF-κB) were...

... and cataract type. In addition, the organophosphate profiles clearly delineate the diabetic cataracts, and the 13 C-NMR spectra correlate well with the age-related decrease in aldose reductase activity 16 11 1987 16 02 1988 10 12 2009 Cataracts Fluorescence spectroscopy NMR...

... biochemical parameters: K + / Na + ratio, aldose reductase activity, level of protein and non-protein sulfhydryl (SH) groups. Vitamin E was given parenterally at a dose of 100 mg/kg/day. The K + /Na + ratio drops after 15 days of galactosemia, while the level of the aldose reductase rises after only 5 days...

... available techniques were made in order to localize glucose-6-phosphate dehydrogenase, aldose reductase, sorbitol dehydrogenase, hexokinase and ketohexokinase in ocular lens. Human cataractous lenses showed a precipitous drop in glucose-6-phosphate dehydrogenase activity, whereas the lenticular tissues...

...P. Müller; O. Hockwin; C. Ohrloff The inhibition constants of several aldose reductase inhibitors were determined using water-soluble extracts of bovine and rat lenses. The most potent inhibitor was the Alcon compound AL-1576; the inhibitory effects of AL-1567 and Sorbinil were about equal...

...James C. Crabbe; Gwyneth Freeman; Anjana B. Halder; Anthony J. Bron The protein aldose reductase has been implicated in cataract in diabetes and galactosaemia. Recently it has been suggested that a number of non-steroidal anti-inflammatory agents have inhibitory activity against aldose reductase...

... Ophthalmology University of Bonn, Bonn Key Words. Bovine lens In vitro incubation Sorbitol Diabetic cataract Aldose reductase Abstract. 48 h incubation of bovine lenses was performed in which one lens of a pair was subjected to Catalin (0.6 x 10 1M), the other serving as control. Subsequently...