...Kuiqing Zhao; Hua Yu; Xiaofen Zheng; Jizhong Yang; Xiaowu Wang; Yuping Han; Lijun Jia; Juwei Zhao Purpose: The purpose of this study was to determine the effect of aging on the corneal subbasal nerve plexus (SNP) by employing a wide-field mapping technique of composite images, scanned...

...Kanako Sawada; Miki Hiraoka; Hiroshi Ohguro Background: The DBA/2J mouse strain is known to develop glaucomatous changes. Intraocular pressure (IOP) fluctuations affected by age or antiglaucoma drug administration were compared among three mouse strains, DBA/2J, C57BL/6, and BALB/c. Methods: IOP...

... measurements. arcenkcelebi@gmail.com 14 08 2015 9 01 2016 24 2 2016 © 2016 S. Karger AG, Basel 2016 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form...

...Kazuo Tsubota; Motoko Kawashima; Takaaki Inaba; Murat Dogru; Yoko Ogawa; Shigeru Nakamura; Ken Shinmura; Akihiro Higuchi; Tetsuya Kawakita Recent advances in the understanding of aging have paved a new way of thinking about intervening with the aging process. There is a global agreement...

...Vicki Chrysostomou; Ian A. Trounce; Jonathan G. Crowston Aging is the greatest risk factor for glaucoma, implying that intrinsic age-related changes to retinal ganglion cells, their supporting tissue or both make retinal ganglion cells susceptible to injury. Changes to the ocular vasculature...

..., and a lower rate of tear evaporation. Since age-related changes in human meibum composition and conformation have never been investigated, as a basis for the study of lipid-associated changes with meibomian gland dysfunction, we used the power of infrared spectroscopy to characterize hydrocarbon chain...

... enzyme research to the problems of aging, species variation and anti-cataract drug development. Ophthalmic Res I995;27(suppl 1): 13 17 William B. Rathbun Department of Ophthalmology, University o f Minnesota, Minneapolis, Minn., USA Influence on Lenticular Glutathione Research Key Words Lens Cataract...

...Keith Green A hypothesis is proposed that aging processes in the eye occur as a consequence of degradation of enzymes that normally metabolize and detoxify hydrogen peroxide and other free radicals. The loss of enzyme activity allows hydrogen peroxide, which normally occurs within eye fluids...

...Imran Ahmed Bhutto; Tsugio Amemiya Retinal vasculature changes during aging in normal Wistar Kyoto rats maintained to longevity without known diseases were studied by corrosion casts and scanning electron microscopy (SEM). Six-month-old rat retina showed regular running and arrangement of retinal...

...Kiyoyuki Majima Lens epithelial cells (LECs) from 3 patients with congenital cataract aged 2, 4 and 12 months, respectively, were cultured. The findings were compared with those from 26 eyes of 26 patients with senile cataract, with ages ranging from 60 to 89 years. The significantly higher growth...

... of this model of lens pathology. The average variability in the lenticular autofluorescence measurements was 8.7%. The average ratio between lenticular autofluorescence of the left eye and that of the right eye was 0.99 ± 0.13 SD. There was a strong correlation between age and mean lenticular autofluorescence...

... in 5 healthy subjects, aged 54–58 years. Systemic blood pressure (BP) and intraocular pressure were also measured, and the retinal perfusion pressure was calculated. The measurements were compared to those previously obtained from a younger group of 7 healthy subjects, aged 25–38 years. Total retinal...

... crystallin classes were separated reproducibly by chromatography on Superose 6. The fractions were identified as α H , α L , β H , β L1 , β L2 and low-molecular-weight (LMW) crystallins by their elution order and molecular mass. The results obtained show that during lens aging there is a progressive increase...

...: in Coimbra, Portugal, in 44 healthy controls, 15 haemodialysis and 11 renal failure patients, and in Leiden, The Netherlands, in 57 healthy controls, 23 haemodialysis and 47 renal transplant patients. The increase in lens autofluorescence as a function of age was 42 % higher in the Portuguese controls than...

... proliferative layer. The poly-ADPR glycohydrolase activity decreased, but the poly-ADPR polymerase activity increased during aging. In lens epithelial cells of older animals, the poly-ADP-ribose level and average chain length decreased but the chain number increased. Involvement of DNA break accumulation during...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Acid phosphatase (EC 3.1.3.2) Leucin arylamidase (EC 3.4.1.1) Lens Lens cortex Lens nucleus Aging Leucine-arylamidase inhibition Calf Bovine Lens capsule...

... increase measured in lens nuclei. Differences in calcium content between age groups are discussed. © 1985 S. Karger AG, Basel 1985 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any...

...S. Lerman; O. Hockwin; V. Dragomirescu We are reporting a new, objective and quantitative method for monitoring age-related molecular changes in the human ocular lens in vivo, as expressed by increases in at least two (nontryptophan) fluorescence wavelengths. These data correlate with previously...

...P.M.M. van Haard; B.M. de Man; H.J. Hoenders; J. Wollensak Evaluation of sulfhydryl data derived from the nucleus and cortex of individual human lenses, ranging in age from 40 to 90 years, revealed the following: (a) no significant correlation between the age and the sulfhydryl content of normal...

...-crystallin is enhanced in the presence of p -mercuribenzoate, which is capable of partially dissociating the aggregated protein. The comparison of blue-fluorescent α-crystallin isolated from cow, calf and embryonic lenses shows an age-related increase of blue fluorescence. Blue-fluorescent water-insoluble...