...Qingqing Zheng; Ting Shen; Mengyue Xu; Lingtong Tan; Zeqi Shen; Chaoyang Hong Introduction: One of the most common conditions that causes permanent blindness globally is age-related macular degeneration (AMD). The purpose of the present study was to determine the association between vitamin B1...

...Luca Cedro; Laura Hoffmann; Katja Hatz Introduction: The aim of this large-scale long-term retrospective study was to show the enlargement rate (ER) of geographic atrophy (GA) in age-related macular degeneration (AMD), defined as complete retinal pigment epithelium and outer retinal atrophy (cRORA...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2023 CircularRNA Back splicing Retinoblastoma Age-related macular degeneration Diabetic retinopathy With the development of bioinformatics and transcriptomics...

...Yi Guo; Jinye Wu; Xueying Zheng; Chang Yin; Zhenyu Wu Introduction: Due to its progressive nature, early evaluation and timely prediction of legal blindness are important in patients with neovascular age-related macular degeneration (nAMD). We examined the association between early-stage variation...

...Shoji Notomi; Satomi Shiose; Yosuke Fukuda; Kenichiro Mori; Sawako Hashimoto; Kumiko Kano; Keijiro Ishikawa; Koh-Hei Sonoda Introduction: Drusen and pigmentary abnormality are found as the hallmark to predict progression of age-related macular degeneration (AMD). In Asian populations, exudative AMD...

...Julián Garcia-Garcia; Ricardo Usategui-Martin; Maria Rosa Sanabria; Esther Fernandez-Perez; Juan Jose Telleria; Rosa M. Coco-Martin Age-related macular degeneration (AMD) is a complex, multifactorial, progressive retinal disease that affects millions of people worldwide and has become the leading...

...Lucas Janeschitz-Kriegl; Marco Cattaneo; Hendrik P.N. Scholl Introduction: The accumulation of lipofuscin is a hallmark in the pathogenesis of Stargardt disease type 1 (STGD1) and geographic atrophy (GA) secondary to age-related macular degeneration. Limiting lipofuscin accumulation by inhibiting...

... relationship to ocular disease, focusing on autoimmune uveitis, diabetic retinopathy, age-related macular degeneration, and primary-open angle glaucoma. We discuss findings and limitations of this exciting new area of ophthalmology research and explore possible future disease-modifying treatments...

...Xue Wang; Chaofeng Yu; Jiasong Yang; Yuzhen Liu; Yali Xu; Wensheng Li Background: Conbercept, as a novel vascular endothelial growth factor (VEGF) inhibitor, was approved for the treatment of neovascular age-related macular degeneration (nAMD) in China. Objective: This study aimed to compare...

...Hendrik P.N. Scholl; David Boyer; Andrea Giani; Victor Chong Geographic atrophy (GA) secondary to age-related macular degeneration accounts for close to one-quarter of cases of legal blindness in the USA and the UK. Despite this notable disease burden, the pathophysiology of GA is complex...

...Ziming Xu; Mei Zhang; Qing Zhang; Tingjuan Xu; Liming Tao Background: Although epidemiologic studies have suggested that thyroid disease may be a risk factor for age-related macular degeneration (AMD), this finding is still controversial. Objectives: The aim of this meta-analysis was to investigate...

...Chang-Xi Chen; Mei-Ling Liu; Kai Cao; Mayinuer Yusufu; Jin-Da Wang Objective: This study aims to evaluate the diagnostic value of optical coherence tomography angiography (OCTA) in detecting the choroidal neovascularization (CNV) in age-related macular degeneration (AMD). Methods: A systematic...

...Laura Borchers; Johann Roider; Alexa Klettner Introduction: Anti-VEGF therapy is repeatedly given for an extended period of time to patients when treated for age-related macular degeneration. While short-term effects of anti-VEGF agents on retinal pigment epithelial cells have been investigated...

.... The study participants were patients with wet age-related macular degeneration (AMD) in one eye who developed wet AMD in the contralateral eye, with at least 2 years of follow-up prior to conversion. The Moorfields Eye Hospital database was searched for eligible patients and their data were recorded. Eyes...

... to in the content or advertisements. 2020 Reading speed Variability Repeatability Age-related macular degeneration Low vision Maculopathy Sentences Paragraphs To test reading speed (RS) in a clinical and research setting, standardized reading texts are necessary. Such texts are available...

...Jun Zhang; Zhaohui Liu; Shuqiong Hu; Jian Qi Age-related macular degeneration (AMD) causes irreversible vision loss, and targeted anti-vascular endothelial growth factor (VEGF) therapy is now the most common and effective treatment. The aim of this meta-analysis is to discuss whether genetic...

..., or the use of drugs, and patients are aware of the unreality of these images [ 2, 3 ]. CBS is associated with ocular pathology and visual loss, with the most commonly predisposing disorder being age-related macular degeneration (AMD) [ 4 ]. Other risk factors that have been identified include age, social...

... was to determine RTM in growth rate measurements in patients with geographic atrophy (GA) secondary to age-related macular degeneration. Methods: We conducted a retrospective analysis of the GAIN (NCT01694095) and its extension study, in which individuals 50 years or older with pure GA were followed for a minimum...

...Renzhe Cui; Lianji Tian; Di Lu; Huiying Li; Jun Cui Aims: Oxidative damage plays a vital role in the pathogenesis of age-related macular degeneration (AMD). Exendin-4 (EX4), a glucagon-like peptide-1 receptor agonist, possesses several pharmacological functions, such as anti-inflammatory...

... Multimodal imaging Retinal pigment epithelium Choroidal neovascularization Age-related macular degeneration Laser photocoagulation was performed using a 532-nm argon laser (Visulas Trion; Carl Zeiss, Jena, Germany) in conjunction with a slit-lamp delivery system (Accento; Carl Zeiss). Only 1 eye...