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First page of Bruch’s membrane opening (BMO) based peripapillary OCT-A analysis

Purpose: Peripapillary OCT-A scans are a challenge for vessel density (VD) analysis, being dependent on demarcation of the optic disc. Longitudinal VD analysis requires that each pixel of the OCT-A scan must be at the exact same location during follow-up scans in order to see inter-visit differences. The aim of the present study was to investigate reliability of BMO-based peripapillary OCT-A analysis with and without the implementation of the Anatomical Positioning System (APS) compared to manual analysis. Methods: Thirty-seven eyes were measured twice by OCT-A (Heidelberg OCT II Spectralis) and analysed by the Erlangen Angio-Tool (EA-Tool) with an APS- and BMO-based analysis of the macula and peripapillary region. APS allows alignment of OCT-A scans according to each individual FoBMOC (Fovea-to-Bruch’s Membrane Opening-Center). Peripapillary OCT-A scans were analysed: (I) manually (by the shortest distance of the vertical or horizontal diameter of the optic disc), (II) BMO-based, and (III) BMO-based with APS information. Coefficients of variation (CV) were calculated. Results: Peripapillary mean VD was 42.52±4 and 41.69±4 (manually), 50.29±4 and 48.8±4 (BMO-based), and 44.73±3 and 44.39±4 (BMO-based and APSified) for 1st and 2nd scan, respectively. Peripapillary mean VD yielded a significant difference between the 1st and 2nd scan for manual (p=0.04), but not for BMO-based (p>0.05) and BMO-based and APSified analysis (p>0.05). CV were 10.0 (manually), 8.0 (BMO-based), and 8.0 (BMO-based and APSified). Conclusion: The integration of BMO and APS information into the EA-Tool allows a BMO-based peripapillary VD analysis for long-term OCT-A analysis.

Journal Section:
Ophthalmic Imaging
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The Author(s). Published by S. Karger AG, Basel
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2025
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