X-irradiation of frog eyes with natural and experimentally induced differences in lenticular mitotic activity reveals cataractogenesis to be dependent on the proliferative activity of the germinative zone of the lens epithelium. It has also been found that G₀ cells are sufficiently vulnerable to X-rays to cause opacity if cell division is allowed to occur following irradiation. In every case of X-ray-induced lens opacification, a disruption of the radiating columns shows a strong correlation to the severity of the associated cataract. It is suggested that lens cell damage from ionizing radiation is transduced by mitosis and expressed as an opacity by subsequent errant fiber genesis.

Keywords:
Radiation cataract, Mitosis, Lens epithelium, Frog, Radiating columns, Fiber genesis, Polymorphic nuclei, Triiodothyronine, Temperature, Histopathology
© 1975 S. Karger AG, Basel
1975
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.