Purpose: The purpose of this retrospective study was to evaluate the disorganization of the retinal inner layers (DRIL) as a potential predictive factor of postoperative visual outcome in patients with idiopathic epiretinal membrane (iERM), treated with pars plana vitrectomy (PPV). Methods: Participants in the study were 46 consecutive patients diagnosed with iERM, who underwent PPV. Best corrected visual acuity (BCVA) measurement and spectral-domain optical coherence tomography (SD-OCT) were performed at baseline (preoperatively), and at months 3 and 6 postoperatively. DRIL and additional OCT parameters were assessed at 1-mm-wide foveal centered area. Results: DRIL was observed in 47.8% of patients at baseline. There was statistically significant improvement in BCVA and central retinal thickness (CRT) between baseline and months 6 and 12 in all patients. There was a statistically significant difference in BCVA and CRT change between patients with and without DRIL at months 6 and 12 compared to baseline, showing that there was a correlation between change in BCVA or CRT and baseline DRIL. Ellipsoid zone and external limiting membrane were intact in 91.3 and 95.7%, respectively, not affecting our results. Conclusions: Baseline DRIL has been shown to be predictive of postoperative visual outcome in patients with iERM, treated with PPV.

1.
Bu
SC
,
Kuijer
R
,
Li
XR
,
Hooymans
JM
,
Los
LI
.
Idiopathic epiretinal membrane
.
Retina
.
2014
Dec
;
34
(
12
):
2317
35
.
[PubMed]
0275-004X
2.
Sandali
O
,
El Sanharawi
M
,
Basli
E
,
Bonnel
S
,
Lecuen
N
,
Barale
PO
, et al
Epiretinal membrane recurrence: incidence, characteristics, evolution, and preventive and risk factors
.
Retina
.
2013
Nov-Dec
;
33
(
10
):
2032
8
.
[PubMed]
0275-004X
3.
Klein
R
,
Klein
BE
,
Wang
Q
,
Moss
SE
.
The epidemiology of epiretinal membranes
.
Trans Am Ophthalmol Soc
.
1994
;
92
:
403
25
.
[PubMed]
0065-9533
4.
Mitchell
P
,
Smith
W
,
Chey
T
,
Wang
JJ
,
Chang
A
.
Prevalence and associations of epiretinal membranes. The Blue Mountains Eye Study, Australia
.
Ophthalmology
.
1997
Jun
;
104
(
6
):
1033
40
.
[PubMed]
0161-6420
5.
Fraser-Bell
S
,
Guzowski
M
,
Rochtchina
E
,
Wang
JJ
,
Mitchell
P
.
Five-year cumulative incidence and progression of epiretinal membranes: the Blue Mountains Eye Study
.
Ophthalmology
.
2003
Jan
;
110
(
1
):
34
40
.
[PubMed]
0161-6420
6.
Ng
CH
,
Cheung
N
,
Wang
JJ
,
Islam
AF
,
Kawasaki
R
,
Meuer
SM
, et al
Prevalence and risk factors for epiretinal membranes in a multi-ethnic United States population
.
Ophthalmology
.
2011
Apr
;
118
(
4
):
694
9
.
[PubMed]
0161-6420
7.
Pournaras
CJ
,
Emarah
A
,
Petropoulos
IK
.
Idiopathic macular epiretinal membrane surgery and ILM peeling: anatomical and functional outcomes
.
Semin Ophthalmol
.
2011
Mar
;
26
(
2
):
42
6
.
[PubMed]
0882-0538
8.
Donati
S
,
Caprani
SM
,
Semeraro
F
,
Vinciguerra
R
,
Virgili
G
,
Testa
F
, et al
Morphological and Functional Retinal Assessment in Epiretinal Membrane Surgery
.
Semin Ophthalmol
.
2017
;
32
(
6
):
751
8
.
[PubMed]
0882-0538
9.
Sheales
MP
,
Kingston
ZS
,
Essex
RW
.
Associations between preoperative OCT parameters and visual outcome 3 months postoperatively in patients undergoing vitrectomy for idiopathic epiretinal membrane
.
Graefes Arch Clin Exp Ophthalmol
.
2016
Oct
;
254
(
10
):
1909
17
.
[PubMed]
0721-832X
10.
Scheerlinck
LM
,
van der Valk
R
,
van Leeuwen
R
.
Predictive factors for postoperative visual acuity in idiopathic epiretinal membrane: a systematic review
.
Acta Ophthalmol
.
2015
May
;
93
(
3
):
203
12
.
[PubMed]
1755-375X
11.
Zur
D
,
Iglicki
M
,
Busch
C
,
Invernizzi
A
,
Mariussi
M
,
Loewenstein
A
, et al;
International Retina Group
.
OCT Biomarkers as Functional Outcome Predictors in Diabetic Macular Edema Treated with Dexamethasone Implant
.
Ophthalmology
.
2018
Feb
;
125
(
2
):
267
75
.
[PubMed]
0161-6420
12.
Das
R
,
Spence
G
,
Hogg
RE
,
Stevenson
M
,
Chakravarthy
U
.
Disorganization of Inner Retina and Outer Retinal Morphology in Diabetic Macular Edema
.
JAMA Ophthalmol
.
2018
Feb
;
136
(
2
):
202
8
.
[PubMed]
2168-6165
13.
Cho
KH
,
Park
SJ
,
Woo
SJ
,
Park
KH
.
Correlation between inner-retinal changes and outer-retinal damage in patients with idiopathic epiretinal membrane
.
Retina
.
2018
Dec
;
38
(
12
):
2327
35
.
[PubMed]
1539-2864
14.
Zur
D
,
Iglicki
M
,
Feldinger
L
,
Schwartz
S
,
Goldstein
M
,
Loewenstein
A
, et al
Disorganization of Retinal Inner Layers as a Biomarker for Idiopathic Epiretinal Membrane After Macular Surgery-The DREAM Study
.
Am J Ophthalmol
.
2018
Dec
;
196
:
129
35
.
[PubMed]
0002-9394
15.
Kim
JH
,
Kim
YM
,
Chung
EJ
,
Lee
SY
,
Koh
HJ
.
Structural and functional predictors of visual outcome of epiretinal membrane surgery
.
Am J Ophthalmol
.
2012
Jan
;
153
(
1
):
103
10.e1
.
[PubMed]
0002-9394
16.
Kim
HJ
,
Kang
JW
,
Chung
H
,
Kim
HC
.
Correlation of foveal photoreceptor integrity with visual outcome in idiopathic epiretinal membrane
.
Curr Eye Res
.
2014
Jun
;
39
(
6
):
626
33
.
[PubMed]
0271-3683
17.
Kromer
R
,
Vogt
C
,
Wagenfeld
L
,
Spitzer
MS
,
Stemplewitz
B
.
Predicting Surgical Success in Patients with Idiopathic Epiretinal Membrane Using the Spectral-Domain Optical Coherence Tomography Segmentation Module for Single Retinal Layer Analysis
.
Curr Eye Res
.
2018
Aug
;
43
(
8
):
1024
31
.
[PubMed]
0271-3683
18.
Govetto
A
,
Bhavsar
KV
,
Virgili
G
,
Gerber
MJ
,
Freund
KB
,
Curcio
CA
, et al
Tractional Abnormalities of the Central Foveal Bouquet in Epiretinal Membranes: Clinical Spectrum and Pathophysiological Perspectives
.
Am J Ophthalmol
.
2017
Dec
;
184
:
167
80
.
[PubMed]
0002-9394
19.
Kim
JH
,
Kang
SW
,
Kong
MG
,
Ha
HS
.
Assessment of retinal layers and visual rehabilitation after epiretinal membrane removal
.
Graefes Arch Clin Exp Ophthalmol
.
2013
Apr
;
251
(
4
):
1055
64
.
[PubMed]
0721-832X
20.
Watanabe
A
,
Arimoto
S
,
Nishi
O
.
Correlation between metamorphopsia and epiretinal membrane optical coherence tomography findings
.
Ophthalmology
.
2009
Sep
;
116
(
9
):
1788
93
.
[PubMed]
0161-6420
21.
Okamoto
F
,
Sugiura
Y
,
Okamoto
Y
,
Hiraoka
T
,
Oshika
T
.
Inner nuclear layer thickness as a prognostic factor for metamorphopsia after epiretinal mebrane surgery
.
Retina
.
2015
Oct
;
35
(
10
):
2107
14
.
[PubMed]
0275-004X
22.
Niwa
T
,
Terasaki
H
,
Kondo
M
,
Piao
CH
,
Suzuki
T
,
Miyake
Y
.
Function and morphology of macula before and after removal of idiopathic epiretinal membrane
.
Invest Ophthalmol Vis Sci
.
2003
Apr
;
44
(
4
):
1652
6
.
[PubMed]
0146-0404
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