Background: The study aimed to evaluate outcomes of epiretinal membrane (ERM) peeling in patients with asteroid hyalosis (AH) and to compare them with those from controls without AH. Methods: This is a retrospective matched cohort study of 1,104 consecutive patients who underwent surgery for ERM between January 2004 and February 2014. Patients with AH were included in the study group and were matched for preoperative visual acuity, age, gender, date of surgery, and axial length with control patients without AH selected from the same cohort. The best-corrected visual acuity (BCVA) and central macular thickness (CMT) on optical coherence tomography were measured at baseline and postoperatively with a minimum follow-up period of 12 months. Results: A total of 44 patients were included in the AH group and 44 in the control group. The mean initial BCVA was 0.53 ± 0.21 LogMAR for the AH group vs. 0.49 ± 0.20 LogMAR for the control group, and the mean initial CMT was 419 ± 74 vs. 423 ± 75 µm, respectively. During the follow-up, no significant difference was found regarding the final BCVA at 6 months (0.23 ± 0.14 vs. 0.24 ± 0.17) LogMAR (p = 0.87) and 12 months (0.16 ± 0.09 vs. 0.17 ± 0.12) LogMAR (p = 0.92), despite a tendency toward slower visual recovery for the AH group at 1 month, with a mean BCVA of 0.36 ± 0.12 vs. 0.28 ± 0.18 LogMAR (p = 0.08). No difference was found regarding the progression of CMT at 1.6 and 12 months with a mean CMT of 396 ± 47 vs. 378 ± 55 µm (p = 0.39), 356 ± 39 vs. 365 ± 41 µm (p = 0.48), and 349 ± 68 vs. 352 ± 53 µm (p = 0.87), respectively. Conclusion: Vitrectomy with ERM peeling in patients with AH was beneficial and showed similar functional and anatomical outcomes in both groups. AH does not seem to affect visual improvement or the complication rate after ERM peeling. Therefore, the indications for vitrectomy in case of ERM should not be prompted by the presence of AH.

Keywords:
Pars plana vitrectomy, Functional results, Anatomical results, Epiretinal membrane peeling, Asteroid hyalosis
1.
Benson AH: Diseases of the vitreous: a case of monocular asteroid hyalitis. Trans Ophthalmol Soc UK 1894;14:101-104.
2.
Winkler J, Lünsdorf H: Ultrastructure and composition of asteroid bodies. Invest Ophthalmol Vis Sci 2001;42:902-907.
3.
Jabłońska A, Ciszewska J, Kęcik D: Asteroid hyalosis - current state of knowledge. Klin Oczna 2014;116:272-276.
4.
Bergren RL, Brown GC, Duker JS: Prevalence and association of asteroid hyalosis with systemic diseases. Am J Ophthalmol 1991;111:289-293.
5.
Mitchell P, Wang MY, Wang JJ: Asteroid hyalosis in an older population: the Blue Mountains Eye Study. Ophthalmic Epidemiol 2003;10:331-335.
6.
Yazar Z, Hanioglu S, Karakoç G, et al: Asteroid hyalosis. Eur J Ophthalmol 2001;11:57-61.
7.
Kim JH, Roh MI, Byeon SH, et al: Prevalence of and risk factors for asteroid hyalosis in Seoul, Korea. Retina 2008;28:1515-1521.
8.
Sebag J, Yee KM, Wa CA, et al: Vitrectomy for floaters: prospective efficacy analyses and retrospective safety profile. Retina 2014;34:1062-1068.
9.
Belhassan S, Daoudi R: Low visual acuity and asteroid hyalosis. Pan Afr Med J 2014;18:246.
10.
Browning DJ, Fraser CM: Optical coherence tomography to detect macular edema in the presence of asteroid hyalosis. Am J Ophthalmol 2004;137:959-961.
11.
Hwang JC, Barile GR, Schiff WM, Ober MD, Smith RT, Del Priore LV, Turano MR, Chang S: Optical coherence tomography in asteroid hyalosis. Retina 2006;26:661-665.
12.
Roh YR, Park KH, Woo SJ: Foveal thickness between stratus and spectralis optical coherence tomography in retinal diseases. Korean J Ophthalmol 2013;27:268-275.
13.
Fawzi AA, Vo B, Kriwanek R, Ramkumar HL, et al: Asteroid hyalosis in an autopsy population: the University of California at Los Angeles (UCLA) experience. Arch Ophthalmol 2005;123:486-490.
14.
Hampton GR, Nelsen PT, Hay PB: Viewing through the asteroids. Ophthalmology 1981;88:669-672.
15.
Ikeda T, Sawa H, Koizumi K, et al: Vitrectomy for proliferative diabetic retinopathy with asteroid hyalosis. Retina 1998;18:410-414.
16.
Malecaze F, Caratero C, Caratero A, et al: Some ultrastructural aspects of the vitreoretinal juncture. Ophthalmologica 1985;191:22-28.
17.
Sebag J: Ageing of the vitreous. Eye (Lond) 1987;1:254-262.
18.
Rush RB, Simunovic MP, Aragon AV, et al: Postoperative macular hole formation after vitrectomy with internal limiting membrane peeling for the treatment of epiretinal membrane. Retina 2014;34:890-896.
19.
Parnes RE, Zakov ZN, Novak MA, et al: Vitrectomy in patients with decreased visual acuity secondary to asteroid hyalosis. Am J Ophthalmol 1998;125:703-704.
20.
Feist RM, Morris RE, Witherspoon CD, et al: Vitrectomy in asteroid hyalosis. Retina 1990;10:173-177.
© 2017 S. Karger AG, Basel
2017
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