Purpose: The purpose of this study was to evaluate the anatomical and functional findings in patients with vitreomacular traction (VMT) combined with epiretinal membrane (ERM) in the same eye. Methods: In this retrospective, cross-sectional study, we studied 65 patients with VMT and ERM. In 36 of them, ERM/VMT had a ‘unified' appearance (group Ι) but in 29, VMT and ERM coexisted without an interrelationship (group ΙΙ). All patients were examined with spectral-domain optical coherence tomography (SD-OCT). We recorded the macular thickness, the presence, type and location of macular edema, the horizontal diameter of VMT, ellipsoid zone/external limiting membrane (EZ/ELM) status, the vitreofoveal angle of VMT nasally and temporally and the best corrected visual acuity (BCVA). Results: Group Ι presented with increased macular thickness, a broader adhesion diameter, extensive EZ/ELM defect and decreased BCVA compared to those where VMT and ERM were not intercorrelated. In group I (‘unified' VMT and ERM), cystoid macular edema was found at a greater percentage (41.7%), while in patients where the 2 entities were not intercorrelated, diffuse macular edema was more evident (69%). There was no statistically significant difference between the 2 groups in the vitreofoveal angle temporally and nasally. Conclusions: Macular thickness, type of macular edema, adhesion diameter, the extent of the EZ/ELM defect and BCVA appeared different in cases where VMT and ERM were unified compared to cases where ERM and VMT coexisted but were not intercorrelated.

1.
Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P: The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole. Ophthalmology 2013;120:2611-2619.
2.
Jackson TL, Nicod E, Simpson A, Angelis A, Grimaccia F, Kanavos P: Symptomatic vitreomacular adhesion. Retina 2013;33:1503-1511.
3.
Meuer SM, Myers CE, Klein BE, Swift MK, Huang Y, Gangaputra S, Pak JW, Danis RP, Klein R: The epidemiology of vitreoretinal interface abnormalities as detected by spectral-domain optical coherence tomography: the Beaver Dam Eye Study. Ophthalmology 2015;122:787-795.
4.
Bu SC, Kuijer R, Li XR, Hooymans JM, Los LI: Idiopathic epiretinal membrane. Retina 2014;34:2317-2335.
5.
Sandali O, El Sanharawi M, Basli E, Bonnel S, Lecuen N, Barale PO, Borderie V, Laroche L, Monin C: Epiretinal membrane recurrence: incidence, characteristics, evolution and preventive and risk factors. Retina 2013;33:2032-2038.
6.
Folk J, Adelman R, Flaxel C, Hyman L, Pulido J, Olsen T: Idiopathic Epiretinal Membrane and Vitreomacular Traction Preferred Practice Pattern® guidelines. Ophthalmology 2016;123:P152-P181.
7.
Klein R, Klein BE, Wang Q, Moss SE: The epidemiology of epiretinal membranes. Trans Am Ophthalmol Soc 1994;92:403-425.
8.
Mitchell P, Smith W, Chey T, Wang JJ, Chang A: Prevalence and associations of epiretinal membranes. The Blue Mountains Eye Study, Australia. Ophthalmology 1997;104:1033-1040.
9.
Fraser-Bell S, Guzowski M, Rochtchina E, Wang JJ, Mitchell P: Five-year cumulative incidence and progression of epiretinal membranes: the Blue Mountains Eye Study. Ophthalmology 2003;110:34-40.
10.
Ng CH, Cheung N, Wang JJ, Islam AF, Kawasaki R, Meuer SM, Cotch MF, Klein BE, Klein R, Wong TY: Prevalence and risk factors for epiretinal membranes in a multi-ethnic United States population. Ophthalmology 2011;118:694-699.
11.
Odrobina D, Michalewska Z, Michalewski J, Dzięgielewski K, Nawrocki J: Long-term evaluation of vitreomacular traction disorder in spectral-domain optical coherence tomography. Retina 2011;31:324-331.
12.
Falkner-Radler CI, Glittenberg C, Hagen S, Benesch T, Binder S: Spectral-domain optical coherence tomography for monitoring epiretinal membrane surgery. Ophthalmology 2010;117:798-805.
13.
Michalewski J, Michalewska Z, Cisiecki S, Nawrocki J: Morphologically functional correlations of macular pathology connected with epiretinal membrane formation in spectral optical coherence tomography (SOCT). Graefes Arch Clin Exp Ophthalmol 2007;245:1623-1631.
14.
Cereda M, Caimi A, Bottoni F, Staurenghi G: Optical coherence tomography in eyes with vitreomacular traction. Ophthalmology 2013;120:e46-e47.
15.
Shechtman DL, Dunbar MT: The expanding spectrum of vitreomacular traction. Optometry 2009;80:681-687.
16.
Koizumi H, Spaide RF, Fisher YL, Freund KB, Klancnik JM Jr, Yannuzzi LA: Three-dimensional evaluation of vitreomacular traction and epiretinal membrane using spectral-domain optical coherence tomography. Am J Ophthalmol 2008;145:509-517.
17.
Nigam N, Bartsch DU, Cheng L, Brar M, Yuson RM, Kozak I, Mojana F, Freeman WR: Spectral domain optical coherence tomography for imaging ERM, retinal edema, and vitreomacular interface. Retina 2010;30:246-253.
18.
Tsunoda K, Watanabe K, Akiyama K, Usui T, Noda T: Highly reflective foveal region in optical coherence tomography in eyes with vitreomacular traction or epiretinal membrane. Ophthalmology 2012;119:581-587.
19.
Zhang Z, Dong F, Zhao C, Dai R, Yu W, Zheng L, He F, Yang Z: Natural course of vitreomacular traction syndrome observed by spectral-domain optical coherence tomography. Can J Ophthalmol 2015;50:172-179.
20.
Smiddy WE, Green WR, Michels RG, de la Cruz Z: Ultrastructural studies of vitreomacular traction syndrome. Am J Ophthalmol 1989;107:177-185.
21.
Smiddy WE, Maguire AM, Green WR, Michels RG, de la Cruz Z, Enger C, Jaeger M, Rice TA: Idiopathic epiretinal membranes. Ultrastructural characteristics and clinicopathologic correlation. Ophthalmology 1989;96:811-820.
22.
Theodossiadis PG, Grigoropoulos VG, Kyriaki T, Emfietzoglou J, Vergados J, Nikolaidis P, Theodossiadis GP: Evolution of idiopathic epiretinal membrane studied by optical coherence tomography. Eur J Ophthalmol 2008;18:980-988.
23.
Tzu JH, John VJ, Flynn HW Jr, Smiddy WE, Jackson JR, Isernhagen BA, Carver A, Leonard R, Tabandeh H, Boyer DS, Berrocal MH, Suzuki M, Freund KB, Gross JG: Clinical course of vitreomacular traction managed initially by observation. Ophthalmic Surg Lasers Imaging Retina 2015;46:571-576.
24.
Mayer WJ, Fazekas C, Schumann R, Wolf A, Compera D, Kampik A, Haritoglou C: Functional and morphological correlations before and after video-documented 23-gauge pars plana vitrectomy with membrane and ILM peeling in patients with macular pucker. J Ophthalmol 2015;2015:297239.
25.
Kinoshita T, Imaizumi H, Miyamoto H, Katome T, Semba K, Mitamura Y: Two-year results of metamorphopsia, visual acuity, and optical coherence tomographic parameters after epiretinal membrane surgery. Graefes Arch Clin Exp Ophthalmol 2016;254:1041-1049.
26.
Byon IS, Jo SH, Kwon HJ, Kim KH, Park SW, Lee JE: Changes in visual acuity after idiopathic epiretinal membrane removal: good versus poor preoperative visual acuity. Ophthalmologica 2015;234:127-134.
27.
Ophir A, Martinez MR: Epiretinal membranes and incomplete posterior vitreous detachment in diabetic macular edema, detected by spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci 2011;52:6414-6420.
28.
Watanabe K, Tsunoda K, Mizuno Y, Akiyama K, Noda T: Outer retinal morphology and visual function in patients with idiopathic epiretinal membrane. JAMA Ophthalmol 2013;131:172-177.
29.
Inoue M, Morita S, Watanabe Y, Kaneko T, Yamane S, Kobayashi S, Arakawa A, Kadonosono K: Inner segment/outer segment junction assessed by spectral-domain optical coherence tomography in patients with idiopathic epiretinal membrane. Am J Ophthalmol 2010;150:834-839.
30.
Tsunoda K, Watanabe K, Akiyama K, Usui T, Noda T: Highly reflective foveal region in optical coherence tomography in eyes with vitreomacular traction or epiretinal membrane. Ophthalmology 2012;119:581-587.
31.
Odrobina D, Michalewska Z, Michalewski J, Dzięgielewski K, Nawrocki J: Long-term evaluation of vitreomacular traction disorder in spectral-domain optical coherence tomography. Retina 2011;31:324-331.
32.
Shechtman DL, Dunbar MT: The expanding spectrum of vitreomacular traction. Optometry 2009;80:681-687.
33.
Theodossiadis GP, Grigoropoulos VG, Theodoropoulou S, Datseris I, Theodossiadis PG: Spontaneous resolution of vitreomacular traction demonstrated by spectral-domain optical coherence tomography. Am J Ophthalmol 2014;157:842-851.
34.
Haller JA, Stalmans P, Benz MS, Gandorfer A, Pakola SJ, Girach A, Kampik A, Jaffe GJ, Toth CA; MIVI-TRUST Study Group: Efficacy of intravitreal ocriplasmin for treatment of vitreomacular adhesion: subgroup analyses from two randomized trials. Ophthalmology 2015;122:117-122.
35.
Itoh Y, Levison A, Kaiser P, Srivastava S, Singh R, Ehlers J: Characteristics of epiretinal proliferation: a distinguishing feature of lamellar macular holes. Invest Ophthalmol Vis Sci 2015;56:1213.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.