Antisera against the structural glycoproteins isolated from bovine lens capsule (anti-LSGP), sclera (anti-SSGP) and corneal stroma (anti-CSGP) have been tested on tissues of joint, spleen, pancreas, skin, tendon, heart valve, kidney and cartilage by means of the indirect immunofluorescence technique. Anti-LSGP stains basement membranes and reticular structures in all tissues. Anti-CSGP and anti-SSGP stain all collagenous and reticular connective tissues and, moreover, the vascular basement membranes of small blood vessels although less intensive than with anti-LSGP. The anti-SGP antisera show a very limited organ specificity and their reaction patterns with both ocular and non-ocular structures in mammalian tissues are similar. It is suggested that the detected antigenic relationships between lens capsule, vascular basement membranes of small blood vessels, synovial tissue and cartilage and the relationship between scleral stroma, fibrous joint capsule, synovial tissue and cartilage are important for the understanding of the immunopathology of the connective tissues.

Keywords:
Structural glycoproteins, Immunofluorescence, Antigenic relationships, Basement membranes, Reticular tissue, Collagenous tissue, Joint capsule, Cartilage, Synovial tissue, Kidney
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© 1973 S. Karger AG, Basel
1973
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