We carried out immunohistochemistry in embryonic eye-specific antibodies in the mouse to determine the spatial/temporal expression pattern of c-Fos and c-Jun proteins – the main components of the AP-1 transcription factor, in lens epithelial cells during mouse lens morphogenesis. c-Fos protein expression was detected in the equatorial epithelium at E14.5–P25, with a peak at P1–P8. c-Jun protein expression was detected in equatorial lens epithelial cells at E18.5–P8, with a peak at P1. During these intervals, the anterior epithelium lacked expression of c-Fos and c-Jun. They were not detected in an adult mouse lens. The expression pattern of the AP-1 transcription factor in equatorial epithelium may suggest its role in fiber differentiation.

Keywords:
Lens epithelial cells, Transcription factor, c-Fos, c-Jun, Morphogenesis, Mouse
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© 2004 S. Karger AG, Basel
2004
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