The effect of indomethacin on the Δ9-tetrahydrocannabinol (Δ9-THC)-induced fall in rabbit intraocular pressure (IOP) was determined. A 2% suspension of indomethacin was given topically 1 h before intravenous injection of Δ9-THC. IOP was measured hourly and was compared between groups receiving either Δ9-THC alone or Δ9-THC plus indomethacin. A substantial attenuation of the IOP response to Δ9-THC was caused by indomethacin. Δ9-THC may influence IOP at least in part by a prostaglandin-mediated process. Involvement of the cyclooxygenase pathway offers a common explanation for linking several ocular cannabinoid effects. The latter include a fall in IOP, conjunctival hyperemia and minor inflammation.

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