Mercury, (Hg2+, using 203Hg2+ as a tracer) was accumulated by the rabbit lens in vitro in a concentration-dependent manner. Saturation levels for the metal ion were greater at higher external concentrations of Hg2+ and exceeded those in the bathing media. Autora-diographic examination showed that the 203Hg was concentrated in the anterior epithelium and lens bow. Release of accumulated 203Hg was enhanced by external Hg2+ and dithiothrei-tol but was reduced by lanthanum (La3+). Lanthanum also increased net accumulation of Hg2+. The Hg2+ (10––4M for 24 h) appeared to be toxic as shown by excessive accumulation of sodium and loss of potassium by the lens in vitro. Mercuric ions appear to leave and enter the lens by diffusion, a process which may involve anionic pathways on its anterior surface where it is principally bound in the anterior epithelial cells.

Keywords:
Mercury, Lanthanum, Lens
This content is only available via PDF.
© 1987 S. Karger AG, Basel
1987
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.