Human tear fluid has plasminogen activator activity. The type of plasminogen activator activity in unstimulated and stimulated tears was determined, using antibodies that specifically neutralize tissue plasminogen activator or urokinase. All plasminogen activator activity was tissue plasminogen activator-related in both types of tears. Correlations between activities of β-hexosaminidase, lysozyme and lactate dehydrogenase with tissue plasminogen activator acitvity indicate that the contribution to plasminogen activator activity of conjunctival and corneal epithelium is more important in unstimulated tears than in stimulated tears. In stimulated tears the tissue plasminogen activator activity orginates mainly from the lacrimal gland. It is suggested that a constant concentration of plasminogen activator is released from the lacrimal gland and that this concentration is independent of the secretion rate of tear fluid and that the release from the conjunctiva is due to desquamation of cells.

Keywords:
Human tear fluid, Lacrimal gland, Conjunctiva, Cornea, Plasminogen activator, β-Hexosaminidase, Lysozyme, Lactate dehydrogenase, Excretion
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© 1983 S. Karger AG, Basel
1983
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