Rat lenses were incubated for 24 h in isotonic media with varying concentrations of sodium. Sucrose was used to maintain an osmolarity of 305 mosm. Furosemide, which inhibits coupled sodium chloride transport in other tissues, decreases sodium and rubidium influxes in the lens. An increase in the activity of the NaK-pump with increasing concentrations of sodium in the medium was indicated by an increase in 86Rb influx and by an increase in the concentration and content of potassium. These changes are considered to be secondary to the increase in sodium influx which follows an increase in external sodium.

Keywords:
86Rb influx, Sodium influx, NaK-pump, Rat lens, Cation content, Furosemide
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© 1981 S. Karger AG, Basel
1981
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